Source:http://linkedlifedata.com/resource/pubmed/id/12484517
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2002-12-17
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| pubmed:abstractText |
The aim of this study was to evaluate the effects of moderate-intensity regular exercise and/or an angiotensin converting enzyme (ACE) inhibition on tumor necrosis factor-alpha (TNF-alpha) and glucose and lipid metabolism parameters. Spontaneously hypertensive rats (SHRs) were fed a fructose-rich diet during 16 weeks of either exercise training (Ex group: 20 m/min, 0% grade, 60 min/day, 5 days/week), administration of an ACE inhibitor (TM group: temocapril, 10 mg/kg/day), or a combination of both (TM+Ex group). The systolic blood pressure was reduced exclusively in the TM and TM+Ex group. Epididymal fat pads (EPI) weighed less in the TM+Ex group than in the single-treatment (TM) group. The serum leptin level was significantly and directly correlated with the EPI weight (p < 0.001). The TNF-alpha content per gram of EPI was the highest in the TM+Ex group. In addition, the EPI TNF-alpha level was negatively correlated with both the EPI weight and the serum leptin level (p < 0.001, respectively). In contrast, the TNF-alpha level of skeletal muscles was identical among the groups. The extensor digitorum longus had a significantly higher abundance of TNF-alpha protein than the soleus muscle. These data indicate that the local TNF-alpha expression is tissue-specific, and that upregulation of TNF-alpha in EPI by exercise training and/or ACE inhibition may have contributed to the reduction in fat cell volume via the induction of apoptosis and/or the regulation of metabolic homeostasis.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin-Converting Enzyme...,
http://linkedlifedata.com/resource/pubmed/chemical/Fructose,
http://linkedlifedata.com/resource/pubmed/chemical/Leptin,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazepines,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/temocapril hydrochloride
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| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
0916-9636
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
25
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
919-26
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:12484517-Adipose Tissue,
pubmed-meshheading:12484517-Angiotensin-Converting Enzyme Inhibitors,
pubmed-meshheading:12484517-Animals,
pubmed-meshheading:12484517-Blood Pressure,
pubmed-meshheading:12484517-Diet,
pubmed-meshheading:12484517-Epididymis,
pubmed-meshheading:12484517-Fructose,
pubmed-meshheading:12484517-Hindlimb,
pubmed-meshheading:12484517-Hypertension,
pubmed-meshheading:12484517-Leptin,
pubmed-meshheading:12484517-Male,
pubmed-meshheading:12484517-Motor Activity,
pubmed-meshheading:12484517-Muscle, Skeletal,
pubmed-meshheading:12484517-Myocardium,
pubmed-meshheading:12484517-Organ Size,
pubmed-meshheading:12484517-Rats,
pubmed-meshheading:12484517-Rats, Inbred SHR,
pubmed-meshheading:12484517-Systole,
pubmed-meshheading:12484517-Thiazepines,
pubmed-meshheading:12484517-Tumor Necrosis Factor-alpha,
pubmed-meshheading:12484517-Up-Regulation
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| pubmed:year |
2002
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| pubmed:articleTitle |
Impact of exercise and angiotensin converting enzyme inhibition on tumor necrosis factor-alpha and leptin in fructose-fed hypertensive rats.
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| pubmed:affiliation |
Department of Internal Medicine and Rehabilitation Science, Tohoku University Graduate School of Medicine, Sendai, Japan.
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| pubmed:publicationType |
Journal Article
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