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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2002-12-13
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pubmed:abstractText |
Establishment of planar polarity in the Drosophila compound eye requires precise 90 degrees rotation of the ommatidial clusters during development. We found that the morphogenetic furrow controls the stop of ommatidial rotation at 90 degrees by emitting signals to posterior ommatidial clusters. One such signal, Scabrous, is synthesized in the furrow cells and transported in vesicles to ommatidial row 6-8. Scabrous vesicles are transported through actin-based cellular extensions but not transcytosis. Scabrous functions nonautonomously to control the stop of ommatidial rotation by suppressing nemo activity in the second 45 degrees rotation. We propose that the morphogenetic furrow regulates precise ommatidial rotation by transporting Scabrous and perhaps other factors through actin-based cellular extensions.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytochalasin D,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Green Fluorescent Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Luminescent Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/nemo protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/scabrous protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1534-5807
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
839-50
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:12479809-Actin Cytoskeleton,
pubmed-meshheading:12479809-Animals,
pubmed-meshheading:12479809-Body Patterning,
pubmed-meshheading:12479809-Cell Movement,
pubmed-meshheading:12479809-Cell Polarity,
pubmed-meshheading:12479809-Cell Surface Extensions,
pubmed-meshheading:12479809-Cytochalasin D,
pubmed-meshheading:12479809-Drosophila Proteins,
pubmed-meshheading:12479809-Drosophila melanogaster,
pubmed-meshheading:12479809-Female,
pubmed-meshheading:12479809-Gene Expression Regulation, Developmental,
pubmed-meshheading:12479809-Glycoproteins,
pubmed-meshheading:12479809-Green Fluorescent Proteins,
pubmed-meshheading:12479809-Luminescent Proteins,
pubmed-meshheading:12479809-Male,
pubmed-meshheading:12479809-Microscopy, Fluorescence,
pubmed-meshheading:12479809-Microtubules,
pubmed-meshheading:12479809-Mitogen-Activated Protein Kinases,
pubmed-meshheading:12479809-Mutation,
pubmed-meshheading:12479809-Photoreceptor Cells, Invertebrate,
pubmed-meshheading:12479809-Protein Transport,
pubmed-meshheading:12479809-Recombinant Fusion Proteins,
pubmed-meshheading:12479809-Transport Vesicles
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pubmed:year |
2002
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pubmed:articleTitle |
Scabrous controls ommatidial rotation in the Drosophila compound eye.
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pubmed:affiliation |
Graduate Institute of Life Sciences, National Defense Medical Center and Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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