Source:http://linkedlifedata.com/resource/pubmed/id/12478407
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
2002-12-12
|
| pubmed:abstractText |
Cytomegalovirus (CMV) infection has been shown to increase inflammation in rat liver allografts. In-vitro CMV has been shown to transactivate cyclo-oxygenase-2 (COX-2), while COX-2 plays a role in the CMV replication cycle. Our aim was to investigate the expression of COX-2 in liver allograft rejection and concomitant CMV infection. Expression of COX-2 was studied immunohistologically in rat liver allografts with or without rat CMV infection, in isografts, and in normal rat liver. There were small amounts of COX-2-positive mononuclear inflammatory cells in the normal liver and isografts. Acute rejection increased the amount of COX-2-expressing cells in the portal areas only, whereas concomitant CMV infection did this also in the sinusoid area. COX-2 may play a role in CMV infection in vivo as well. The possible role of COX-2 in the association between CMV infection and allograft rejection warrants further study.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0934-0874
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
15
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
610-4
|
| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:12478407-Animals,
pubmed-meshheading:12478407-Cyclooxygenase 2,
pubmed-meshheading:12478407-Cytomegalovirus,
pubmed-meshheading:12478407-Cytomegalovirus Infections,
pubmed-meshheading:12478407-Enzyme Induction,
pubmed-meshheading:12478407-Graft Rejection,
pubmed-meshheading:12478407-Immunohistochemistry,
pubmed-meshheading:12478407-Inflammation,
pubmed-meshheading:12478407-Isoenzymes,
pubmed-meshheading:12478407-Liver Transplantation,
pubmed-meshheading:12478407-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:12478407-Rats,
pubmed-meshheading:12478407-Rats, Inbred BN,
pubmed-meshheading:12478407-Rats, Inbred Strains,
pubmed-meshheading:12478407-Time Factors,
pubmed-meshheading:12478407-Transcriptional Activation,
pubmed-meshheading:12478407-Transplantation, Homologous,
pubmed-meshheading:12478407-Virus Replication
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Induction of cyclo-oxygenase-2 by acute liver allograft rejection and cytomegalovirus infection in the rat.
|
| pubmed:affiliation |
Department of Surgery, Transplant Unit Research Laboratory, Helsinki University Hospital, Kasarmikatu 11-13, 00130 Helsinki, Finland. tmarteli@helsinki.fi
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|