Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2002-12-10
pubmed:abstractText
Neurogenesis occurs in the adult mammalian brain and may play roles in learning and memory processes and recovery from injury, suggesting that abnormalities in neural progenitor cells (NPC) might contribute to the pathogenesis of disorders of learning and memory in humans. The objectives of this study were to determine whether NPC proliferation, survival and neuronal differentiation are impaired in a transgenic mouse model of Alzheimer's disease (AD), and to determine the effects of the pathogenic form of amyloid beta-peptide (Abeta) on the survival and neuronal differentiation of cultured NPC. The proliferation and survival of NPC in the dentate gyrus of the hippocampus was reduced in mice transgenic for a mutated form of amyloid precursor protein that causes early onset familial AD. Abeta impaired the proliferation and neuronal differentiation of cultured human and rodent NPC, and promoted apoptosis of neuron-restricted NPC by a mechanism involving dysregulation of cellular calcium homeostasis and the activation of calpains and caspases. Adverse effects of Abeta on NPC may contribute to the depletion of neurons and cognitive impairment in AD.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0022-3042
pubmed:author
pubmed:issnType
Print
pubmed:volume
83
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1509-24
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:12472904-Alzheimer Disease, pubmed-meshheading:12472904-Amyloid beta-Peptides, pubmed-meshheading:12472904-Animals, pubmed-meshheading:12472904-Antigens, Differentiation, pubmed-meshheading:12472904-Apoptosis, pubmed-meshheading:12472904-Calcium, pubmed-meshheading:12472904-Calpain, pubmed-meshheading:12472904-Caspases, pubmed-meshheading:12472904-Cell Differentiation, pubmed-meshheading:12472904-Cell Division, pubmed-meshheading:12472904-Cell Survival, pubmed-meshheading:12472904-Cells, Cultured, pubmed-meshheading:12472904-Dentate Gyrus, pubmed-meshheading:12472904-Disease Models, Animal, pubmed-meshheading:12472904-Homeostasis, pubmed-meshheading:12472904-Humans, pubmed-meshheading:12472904-Male, pubmed-meshheading:12472904-Mice, pubmed-meshheading:12472904-Mice, Transgenic, pubmed-meshheading:12472904-Mutation, pubmed-meshheading:12472904-Neurons, pubmed-meshheading:12472904-Peptide Fragments, pubmed-meshheading:12472904-Stem Cells
pubmed:year
2002
pubmed:articleTitle
Disruption of neurogenesis by amyloid beta-peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's disease.
pubmed:affiliation
Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, Baltimore, Maryland 21224, USA.
pubmed:publicationType
Journal Article