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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2002-12-6
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pubmed:abstractText |
Misshapen (Msn) has been proposed to shut down Drosophila photoreceptor (R cell) growth cone motility in response to targeting signals linked by the SH2/SH3 adaptor protein Dock. Here, we show that Bifocal (Bif), a putative cytoskeletal regulator, is a component of the Msn pathway for regulating R cell growth cone targeting. bif displays strong genetic interaction with msn. Phenotypic analysis indicates a specific role for Bif to terminate R1-R6 growth cones. Biochemical studies show that Msn associates directly with Bif and phosphorylates Bif in vitro. Cell culture studies demonstrate that Msn interacts with Bif to regulate F-actin structure and filopodium formation. We propose that Bif functions downstream of Msn to reorganize actin cytoskeleton in decelerating R cell growth cone motility at the target region.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Eye Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Green Fluorescent Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Luminescent Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/bifocal protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/misshapen protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0896-6273
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
831-42
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12467587-Animals,
pubmed-meshheading:12467587-Cell Movement,
pubmed-meshheading:12467587-Cells, Cultured,
pubmed-meshheading:12467587-Cytoskeletal Proteins,
pubmed-meshheading:12467587-Cytoskeleton,
pubmed-meshheading:12467587-Drosophila Proteins,
pubmed-meshheading:12467587-Drosophila melanogaster,
pubmed-meshheading:12467587-Eye Proteins,
pubmed-meshheading:12467587-Gene Dosage,
pubmed-meshheading:12467587-Green Fluorescent Proteins,
pubmed-meshheading:12467587-Growth Cones,
pubmed-meshheading:12467587-Luminescent Proteins,
pubmed-meshheading:12467587-Phosphorylation,
pubmed-meshheading:12467587-Photoreceptor Cells, Invertebrate,
pubmed-meshheading:12467587-Protein Binding,
pubmed-meshheading:12467587-Protein-Serine-Threonine Kinases,
pubmed-meshheading:12467587-Pseudopodia,
pubmed-meshheading:12467587-Recombinant Fusion Proteins,
pubmed-meshheading:12467587-Signal Transduction
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pubmed:year |
2002
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pubmed:articleTitle |
Bifocal is a downstream target of the Ste20-like serine/threonine kinase misshapen in regulating photoreceptor growth cone targeting in Drosophila.
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pubmed:affiliation |
McGill Centre for Research in Neuroscience, Montreal, Quebec, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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