|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
12
|
|
pubmed:dateCreated |
2002-12-11
|
|
pubmed:abstractText |
C2H2 zinc-finger proteins (ZFPs) constitute the largest family of nucleic acid binding factors in higher eukaryotes. In silico analysis identified a total of 326 putative ZFP genes in the Drosophila genome, corresponding to approximately 2.3% of the annotated genes. Approximately 29% of the Drosophila ZFPs are evolutionary conserved in humans and/or Caenorhabditis elegans. In addition, approximately 28% of the ZFPs contain an N-terminal zinc-finger-associated C4DM domain (ZAD) consisting of approximately 75 amino acid residues. The ZAD is restricted to ZFPs of dipteran and closely related insects. The evolutionary restriction, an expansion of ZAD-containing ZFP genes in the Drosophila genome and their clustering at few chromosomal sites are features reminiscent of vertebrate KRAB-ZFPs. ZADs are likely to represent protein-protein interaction domains. We propose that ZAD-containing ZFP genes participate in transcriptional regulation either directly or through site-specific modification and/or regulation of chromatin.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446571-10465787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446571-10471706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446571-10660560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446571-10683177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446571-10731134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446571-10924478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446571-11118137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446571-11181995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446571-11237011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446571-11238992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446571-11275326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446571-11340155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446571-11751581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446571-11752248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446571-11752305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446571-11752314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446571-12097341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446571-1516821,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446571-2081456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446571-2107402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446571-2331751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446571-2492966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446571-2507923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446571-2710781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446571-6776413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446571-7958928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446571-7984417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446571-8743704,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446571-8759004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446571-9154812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446571-9171100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446571-9254694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446571-9851918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446571-9851920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446571-9918945
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
1469-221X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
3
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1158-62
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:12446571-Amino Acid Sequence,
pubmed-meshheading:12446571-Animals,
pubmed-meshheading:12446571-Drosophila,
pubmed-meshheading:12446571-Evolution, Molecular,
pubmed-meshheading:12446571-Genome,
pubmed-meshheading:12446571-Introns,
pubmed-meshheading:12446571-Molecular Sequence Data,
pubmed-meshheading:12446571-Multigene Family,
pubmed-meshheading:12446571-Mutation,
pubmed-meshheading:12446571-Protein Structure, Tertiary,
pubmed-meshheading:12446571-Sequence Alignment,
pubmed-meshheading:12446571-Sequence Analysis, DNA,
pubmed-meshheading:12446571-Zinc Fingers
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
Genomic expansion and clustering of ZAD-containing C2H2 zinc-finger genes in Drosophila.
|
|
pubmed:affiliation |
Abteilung Molekulare Entwicklungsbiologie, Max-Planck-Institut für biophysikalische Chemie, Am Fassberg, D-37077 Göttingen, Germany.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
