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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2002-12-11
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pubmed:abstractText |
Blood cells play a crucial role in both morphogenetic and immunological processes in Drosophila, yet the factors regulating their proliferation remain largely unknown. In order to address this question, we raised antibodies against a tumorous blood cell line and identified an antigenic determinant that marks the surface of prohemocytes and also circulating plasmatocytes in larvae. This antigen was identified as a Drosophila homolog of the mammalian receptor for platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF). The Drosophila receptor controls cell proliferation in vitro. By overexpressing in vivo one of its putative ligands, PVF2, we induced a dramatic increase in circulating hemocytes. These results identify the PDGF/VEGF receptor homolog and one of its ligands as important players in Drosophila hematopoiesis.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446570-10207096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446570-10753120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446570-11161576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446570-11595182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446570-11677054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446570-11696329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446570-11812988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446570-11912489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446570-11955438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446570-11980713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446570-12032772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446570-1587256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446570-6786941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446570-7729418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446570-7796812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446570-7924990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446570-8479437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446570-8630729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446570-9177203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446570-9474784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446570-9779982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12446570-9784499
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1469-221X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1195-200
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12446570-Animals,
pubmed-meshheading:12446570-Antibodies,
pubmed-meshheading:12446570-Blotting, Western,
pubmed-meshheading:12446570-Cell Differentiation,
pubmed-meshheading:12446570-Drosophila,
pubmed-meshheading:12446570-Hemocytes,
pubmed-meshheading:12446570-Immunohistochemistry,
pubmed-meshheading:12446570-Larva,
pubmed-meshheading:12446570-Ligands,
pubmed-meshheading:12446570-Receptors, Platelet-Derived Growth Factor,
pubmed-meshheading:12446570-Receptors, Vascular Endothelial Growth Factor
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pubmed:year |
2002
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pubmed:articleTitle |
PVF2, a PDGF/VEGF-like growth factor, induces hemocyte proliferation in Drosophila larvae.
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pubmed:affiliation |
Institut de Biologie Moléculaire et Cellulaire, CNRS UPR 9022, 15 rue Descartes, 67084 Strasbourg, France.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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