Linked Life Data

12433364

Source:http://linkedlifedata.com/resource/pubmed/id/12433364

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2002-11-15
pubmed:abstractText
Drosophila responds to Gram-negative infections by mounting an immune response that depends on components of the IMD pathway. We recently showed that imd encodes a protein with a death domain with high similarity to that of mammalian RIP. Using a two-hybrid screen in yeast, we have isolated the death protein dFADD as a molecule that associates with IMD. Our data show that loss of dFADD function renders flies highly susceptible to Gram-negative infections without affecting resistance to Gram-positive bacteria. By genetic analysis we show that dFADD acts downstream of IMD in the pathway that controls inducibility of the antibacterial peptide genes.
pubmed:grant
pubmed:language
eng
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:author
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
575-81
pubmed:dateRevised
2007-11-14
pubmed:articleTitle
The Drosophila immune defense against gram-negative infection requires the death protein dFADD.
pubmed:affiliation
Institut de Biologie Moleculaire et Cellulaire, UPR 9022 du CNRS, 15 Rue René Descartes, 67084 Cedex, Strasbourg, France. s.naitza@ibmc.u-strasbg.fr