Linked Life Data

12408822

Source:http://linkedlifedata.com/resource/pubmed/id/12408822

Statements in which the resource exists.
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pubmed-article:12408822pubmed:abstractTextIn Drosophila, two features of small interfering RNA (siRNA) structure--5' phosphates and 3' hydroxyls--are reported to be essential for RNA interference (RNAi). Here, we show that as in Drosophila, a 5' phosphate is required for siRNA function in human HeLa cells. In contrast, we find no evidence in flies or humans for a role in RNAi for the siRNA 3' hydroxyl group. Our in vitro data suggest that in both flies and mammals, each siRNA guides endonucleolytic cleavage of the target RNA at a single site. We conclude that the underlying mechanism of RNAi is conserved between flies and mammals and that RNA-dependent RNA polymerases are not required for RNAi in these organisms.lld:pubmed
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pubmed-article:12408822pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:12408822pubmed:articleTitleEvidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways.lld:pubmed
pubmed-article:12408822pubmed:affiliationDepartment of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.lld:pubmed
pubmed-article:12408822pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12408822pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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