Linked Life Data

12397637

Source:http://linkedlifedata.com/resource/pubmed/id/12397637

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2002-10-24
pubmed:abstractText
We assessed the exposure of total N-nitroso compounds (TNOCs) in the inhabitants of high- and low-risk areas for esophageal cancer in southern China. Samples of 24 hr diet and 12 hr overnight urine were collected from 120 male adults in each of the 2 areas, a high-risk area (Nan'ao County) and a low-risk area (Lufeng County) for esophageal cancer. Annual standardized mortality rates of esophageal cancer in Nan'ao and Lufeng are 110/10(6) and 10/10(6) respectively. The 240 healthy male subjects (35-64 years old) were selected by a 3-stage random cluster sample procedure. Levels of TNOCs, NAAs and volatile nitrosamines in the samples were measured. The TNOC detection rate (95%) in the diet, the TNOC daily intake (4.25 +/- 0.84 micromol), TNOC excretion levels (0.04 +/- 0.01 nmol/12 hr) and daily intake of volatile nitrosamines (5.84 +/- 0.71 micromol) in the high-risk area were significantly greater than values in the low-risk area (A +/- B = mean +/- SE). The TNOC detection rate in the diet, the TNOC daily intake, TNOC excretion levels and daily intake of volatile nitrosamines in the low-risk area were 70%, 0.25 +/- 0.06 micromol, 0.02 +/- 0.01 nmol/12 hr and 3.18 +/- 0.31 micromol, respectively. NAA excretion levels showed no difference between the 2 areas (16.3 +/- 7.18 micromol/12 hr for Nan'ao and 31.2 +/- 26.4 micromol/12 hr for Lufeng). Thus, TNOCs are implicated in the etiology of esophageal cancer in southern China.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/4-nitrophenyl..., http://linkedlifedata.com/resource/pubmed/chemical/4-nitrosodimethylaniline, http://linkedlifedata.com/resource/pubmed/chemical/Carboxylic Acids, http://linkedlifedata.com/resource/pubmed/chemical/Diethylnitrosamine, http://linkedlifedata.com/resource/pubmed/chemical/Dimethylnitrosamine, http://linkedlifedata.com/resource/pubmed/chemical/Inositol Phosphates, http://linkedlifedata.com/resource/pubmed/chemical/N-Nitrosopyrrolidine, http://linkedlifedata.com/resource/pubmed/chemical/N-nitroso(di-n-propyl)amine, http://linkedlifedata.com/resource/pubmed/chemical/N-nitroso-2-methylthiazolidine-4-car..., http://linkedlifedata.com/resource/pubmed/chemical/N-nitrosopiperidine, http://linkedlifedata.com/resource/pubmed/chemical/N-nitrososarcosine, http://linkedlifedata.com/resource/pubmed/chemical/N-nitrosothiazolidine-4-carboxylic..., http://linkedlifedata.com/resource/pubmed/chemical/Nitrosamines, http://linkedlifedata.com/resource/pubmed/chemical/Nitroso Compounds, http://linkedlifedata.com/resource/pubmed/chemical/Thiazoles, http://linkedlifedata.com/resource/pubmed/chemical/Thiazolidines, http://linkedlifedata.com/resource/pubmed/chemical/nitrosobenzylmethylamine, http://linkedlifedata.com/resource/pubmed/chemical/nitrosoproline
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0020-7136
pubmed:author
pubmed:copyrightInfo
Copyright 2002 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
102
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
207-11
pubmed:dateRevised
2007-7-24
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Dietary exposure and urinary excretion of total N-nitroso compounds, nitrosamino acids and volatile nitrosamine in inhabitants of high- and low-risk areas for esophageal cancer in southern China.
pubmed:affiliation
Department of Hygiene, Shantou University Medical College, 22 Xin Ling Road, 515031 Shantou, People's Republic of China. Klin@mailserv.stu.edu.cn
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't