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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2002-10-21
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pubmed:abstractText |
Histamine H(1),H(2), and H(3) receptors are expressed by osteoblastic MC3T3-E1 (E1) cells derived from mouse calvaria. Expression of the osteoclast differentiation factor (ODF)/receptor activator of nuclear factor-kappaB ligand (RANKL) transcript was induced in E1 cells and bone marrow stromal cells (ST2). Histamine markedly increased the steady-state level of ODF/RANKL mRNA in a dose-dependent manner. The effect of histamine on expression of ODF/RANKL mRNA by E1 cells was transient, with a peak at 6h. Western blot analysis revealed that histamine increased production of ODF/RANKL protein by E1 cells at 12h. In cocultures of E1 cells and mouse bone marrow cells, histamine stimulated osteoclastogenesis in the presence of 1,25-dihydroxyvitamin D(3) and this effect was blocked by preincubation with neutralizing antibody against ODF/RANKL. These results suggest that histamine regulates osteoclastogenesis, at least in part, through induction of ODF/RANKL expression by osteoblasts and bone marrow stromal cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Histamine,
http://linkedlifedata.com/resource/pubmed/chemical/Histamine Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/RANK Ligand,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Activator of Nuclear...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Histamine,
http://linkedlifedata.com/resource/pubmed/chemical/Tnfrsf11a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tnfsf11 protein, mouse
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
25
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pubmed:volume |
298
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
240-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12387822-Animals,
pubmed-meshheading:12387822-Bone Marrow Cells,
pubmed-meshheading:12387822-Carrier Proteins,
pubmed-meshheading:12387822-Cell Line,
pubmed-meshheading:12387822-Cells, Cultured,
pubmed-meshheading:12387822-Coculture Techniques,
pubmed-meshheading:12387822-Dose-Response Relationship, Drug,
pubmed-meshheading:12387822-Gene Expression Regulation,
pubmed-meshheading:12387822-Histamine,
pubmed-meshheading:12387822-Histamine Antagonists,
pubmed-meshheading:12387822-Membrane Glycoproteins,
pubmed-meshheading:12387822-Mice,
pubmed-meshheading:12387822-Mice, Inbred C57BL,
pubmed-meshheading:12387822-Osteoblasts,
pubmed-meshheading:12387822-Osteoclasts,
pubmed-meshheading:12387822-RANK Ligand,
pubmed-meshheading:12387822-RNA, Messenger,
pubmed-meshheading:12387822-Receptor Activator of Nuclear Factor-kappa B,
pubmed-meshheading:12387822-Receptors, Histamine,
pubmed-meshheading:12387822-Stromal Cells
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pubmed:year |
2002
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pubmed:articleTitle |
Histamine stimulates production of osteoclast differentiation factor/receptor activator of nuclear factor-kappaB ligand by osteoblasts.
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pubmed:affiliation |
Division of Molecular Cell Pharmacology, Department of Oral Pathobiological Science, Graduate School of Dental Medicine, Hokkaido University, Kita 13, Nishi 7, Kita-ku, Sapporo 060-8586, Japan. dey@den.hokudai.ac.jp
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pubmed:publicationType |
Journal Article
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