Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
20
pubmed:dateCreated
2002-10-16
pubmed:abstractText
Apoptotic cell death is accompanied by degradation of chromosomal DNA. Here, we established in Drosophila a null mutation in the gene for inhibitor of caspase-activated DNase (ICAD) by P-element insertion. We also identified a loss-of-function mutant in Drosophila for DNase II-like acid DNase. The flies deficient in the ICAD gene did not express CAD, and did not undergo apoptotic DNA fragmentation during embryogenesis and oogenesis. In contrast, the deficiency of DNase II enhanced the apoptotic DNA fragmentation in the embryos and ovary, but paradoxically, the mutant flies accumulated a large amount of DNA, particularly in the ovary. This accumulation of DNA in the DNase II mutants caused the constitutive expression of the antibacterial genes for diptericin and attacin, which are usually activated during bacterial infection. The expression of these genes was further enhanced in flies lacking both dICAD and DNase II. These results indicated that CAD and DNase II work independently to degrade chromosomal DNA during apoptosis, and if the DNA is left undigested, it can activate the innate immunity in Drosophila.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-10336474, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-10403638, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-10511707, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-10713130, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-10713148, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-10716942, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-10716943, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-10739646, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-10777599, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-10781612, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-10872455, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-10908589, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-10952730, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-11017107, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-11130078, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-11241278, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-11375492, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-11452313, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-11452314, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-11753562, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-11812988, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-11912488, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-11948342, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-12000961, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-12072368, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-1400587, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-16465212, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-1659816, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-2125051, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-6245367, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-6406021, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-6628361, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-7014501, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-7806546, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-8171319, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-823072, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-8382177, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-8999799, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-9039261, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-9108473, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-9405661, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-9422506, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-9422513, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-9422696, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-9463354, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-9569352, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-9700717, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-9721091, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-9770511, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-9894605, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-9916984, http://linkedlifedata.com/resource/pubmed/commentcorrection/12381665-9988219
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Attacin-A protein, Drosophila, http://linkedlifedata.com/resource/pubmed/chemical/Attacin-B protein, Drosophila, http://linkedlifedata.com/resource/pubmed/chemical/Attacin-C protein, Drosophila, http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers, http://linkedlifedata.com/resource/pubmed/chemical/Dpt protein, Drosophila, http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Endodeoxyribonucleases, http://linkedlifedata.com/resource/pubmed/chemical/Insect Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins, http://linkedlifedata.com/resource/pubmed/chemical/attacin antibacterial protein..., http://linkedlifedata.com/resource/pubmed/chemical/caspase-activated DNase inhibitor, http://linkedlifedata.com/resource/pubmed/chemical/deoxyribonuclease II
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0890-9369
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2662-71
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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