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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2002-10-10
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pubmed:abstractText |
Parathyroid hormone-related protein (PTHRP) is in part responsible for the clinical syndrome of hypercalcaemia of malignancy and has been implicated as an important factor in the development of bone metastases. The aim of this study was to determine the coexpression of PTHRP and its receptor in early breast cancer (EBC) and bone metastases (BM), and correlate these findings to clinical outcome. Experimental Design: Samples of surgically excised EBC (n = 176) and BM (n = 43) were collected and stored in liquid nitrogen. PTHRP protein was determined using immunohistochemistry and receptor mRNA using in situ hybridization (n = 107) or semiquantitative reverse transcription-PCR (n = 69).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Probes,
http://linkedlifedata.com/resource/pubmed/chemical/Ki-67 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/PTHLH protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Parathyroid Hormone-Related Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Parathyroid Hormone...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Estrogen,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Parathyroid Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Progesterone
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3172-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12374685-Aged,
pubmed-meshheading:12374685-Bone Neoplasms,
pubmed-meshheading:12374685-Breast Neoplasms,
pubmed-meshheading:12374685-DNA, Complementary,
pubmed-meshheading:12374685-DNA Primers,
pubmed-meshheading:12374685-DNA Probes,
pubmed-meshheading:12374685-Female,
pubmed-meshheading:12374685-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:12374685-Humans,
pubmed-meshheading:12374685-Immunoenzyme Techniques,
pubmed-meshheading:12374685-In Situ Hybridization,
pubmed-meshheading:12374685-Ki-67 Antigen,
pubmed-meshheading:12374685-Middle Aged,
pubmed-meshheading:12374685-Parathyroid Hormone-Related Protein,
pubmed-meshheading:12374685-Peptide Hormones,
pubmed-meshheading:12374685-Polymerase Chain Reaction,
pubmed-meshheading:12374685-RNA, Messenger,
pubmed-meshheading:12374685-Receptor, Parathyroid Hormone, Type 1,
pubmed-meshheading:12374685-Receptors, Estrogen,
pubmed-meshheading:12374685-Receptors, Parathyroid Hormone,
pubmed-meshheading:12374685-Receptors, Progesterone,
pubmed-meshheading:12374685-Reverse Transcriptase Polymerase Chain Reaction
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pubmed:year |
2002
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pubmed:articleTitle |
Coexpression of parathyroid hormone related protein and its receptor in early breast cancer predicts poor patient survival.
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pubmed:affiliation |
Academic Department of Surgery, Division of Cancer Studies, Schools of Medicine, University of Manchester, Manchester M23 9LT, United Kingdom.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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