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rdf:type |
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lifeskim:mentions |
umls-concept:C0002260,
umls-concept:C0005516,
umls-concept:C0006142,
umls-concept:C0008976,
umls-concept:C0011923,
umls-concept:C0042036,
umls-concept:C0205390,
umls-concept:C0229671,
umls-concept:C0278925,
umls-concept:C0442027,
umls-concept:C1521747
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pubmed:issue |
10
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pubmed:dateCreated |
2002-10-10
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pubmed:abstractText |
A double-blind randomized Phase II chemoprevention trial of alpha-difluoromethylornithine (DFMO) was conducted in a group of women at high risk for development of breast cancer. DFMO is an irreversible inhibitor of ornithine decarboxylase, the limiting enzyme of polyamine synthesis that is often up-regulated in breast cancer. Experimental Design: Study entrants were required to have random periareolar fine-needle aspiration cytology prior to entry that exhibited hyperplasia or hyperplasia with atypia, as well as a mammogram and clinical breast exam judged as not suspicious for breast cancer and no clinical hearing loss. Subjects were randomized to 6 months of oral DFMO (0.5 g/m(2)/day) or placebo, followed by repeat fine-needle aspiration and biomarker assessment. The main study end point was an improvement in cytologic pattern.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Eflornithine,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor Binding...,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor I,
http://linkedlifedata.com/resource/pubmed/chemical/Polyamines,
http://linkedlifedata.com/resource/pubmed/chemical/Proliferating Cell Nuclear Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:ArnesonDora WDW,
pubmed-author:BoydNorman FNF,
pubmed-author:BradyDeborah ADA,
pubmed-author:ChangC H JosephCH,
pubmed-author:FabianCarol JCJ,
pubmed-author:FerraroJohn AJA,
pubmed-author:GrizzleWilliam EWE,
pubmed-author:JohnsonKaren AKA,
pubmed-author:KimlerBruce FBF,
pubmed-author:MasoodShahlaS,
pubmed-author:MayoMatthew SMS,
pubmed-author:StantonAnnette LAL,
pubmed-author:ZallesCarola MCM
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3105-17
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12374678-Administration, Oral,
pubmed-meshheading:12374678-Antineoplastic Agents,
pubmed-meshheading:12374678-Biopsy, Needle,
pubmed-meshheading:12374678-Breast Neoplasms,
pubmed-meshheading:12374678-Double-Blind Method,
pubmed-meshheading:12374678-Eflornithine,
pubmed-meshheading:12374678-Enzyme Inhibitors,
pubmed-meshheading:12374678-Female,
pubmed-meshheading:12374678-Hormones,
pubmed-meshheading:12374678-Humans,
pubmed-meshheading:12374678-Insulin-Like Growth Factor Binding Protein 3,
pubmed-meshheading:12374678-Insulin-Like Growth Factor I,
pubmed-meshheading:12374678-Mammography,
pubmed-meshheading:12374678-Middle Aged,
pubmed-meshheading:12374678-Neoplasm Staging,
pubmed-meshheading:12374678-Polyamines,
pubmed-meshheading:12374678-Proliferating Cell Nuclear Antigen,
pubmed-meshheading:12374678-Quality of Life,
pubmed-meshheading:12374678-Receptor, Epidermal Growth Factor,
pubmed-meshheading:12374678-Tumor Markers, Biological,
pubmed-meshheading:12374678-Tumor Suppressor Protein p53
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pubmed:year |
2002
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pubmed:articleTitle |
A phase II breast cancer chemoprevention trial of oral alpha-difluoromethylornithine: breast tissue, imaging, and serum and urine biomarkers.
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pubmed:affiliation |
University of Kansas Medical Center, Kansas City, Kansas 66160, USA. cfabian@kumc.edu
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Randomized Controlled Trial,
Clinical Trial, Phase II
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