Source:http://linkedlifedata.com/resource/umls/id/C0002260
MSH: An inhibitor of ornithine decarboxylase, the rate limiting enzyme of the polyamine biosynthetic pathway.,NCI: A substance that is being studied in the prevention of cancer. It belongs to the family of drugs called antiprotozoals.,NCI: A difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells. This agent has been shown to induce apoptosis in leiomyoma cells. (NCI04),PDQ: A difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization an