|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0026769,
umls-concept:C0030705,
umls-concept:C0040300,
umls-concept:C0175677,
umls-concept:C0205219,
umls-concept:C0205251,
umls-concept:C0221198,
umls-concept:C0228174,
umls-concept:C0231170,
umls-concept:C1550025,
umls-concept:C2346689
|
|
pubmed:issue |
10
|
|
pubmed:dateCreated |
2002-10-10
|
|
pubmed:abstractText |
Although in situ pathological studies and in vivo magnetic resonance (MR) investigations have shown that axonal injury can be significant in the early stages of multiple sclerosis (MS), diffuse axonal injury is generally considered a secondary event. Cerebral axonal damage can be specifically assessed in vivo by measuring levels of brain N-acetylaspartate (NAA, a specific index of axonal integrity detected by MR spectroscopy). Other new MR measurements such as magnetization transfer ratio (MTr) or computed estimation of brain volume can provide less specific indexes of tissue damage.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0003-9942
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
59
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1565-71
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:12374493-Adolescent,
pubmed-meshheading:12374493-Adult,
pubmed-meshheading:12374493-Brain,
pubmed-meshheading:12374493-Diffuse Axonal Injury,
pubmed-meshheading:12374493-Disabled Persons,
pubmed-meshheading:12374493-Disease Progression,
pubmed-meshheading:12374493-Female,
pubmed-meshheading:12374493-Humans,
pubmed-meshheading:12374493-Magnetic Resonance Imaging,
pubmed-meshheading:12374493-Male,
pubmed-meshheading:12374493-Middle Aged,
pubmed-meshheading:12374493-Multiple Sclerosis
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
Diffuse axonal and tissue injury in patients with multiple sclerosis with low cerebral lesion load and no disability.
|
|
pubmed:affiliation |
Institute of Neurological Sciences, University of Siena, Viale Bracci 2, 53100, Siena, Italy. destefano@unisi.it
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
