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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2002-10-8
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pubmed:abstractText |
The expression of transforming growth factor alpha (TGFalpha), amphiregulin (AR) and cripto-1 (CR-1) was assessed by immunohistochemistry in 83 specimens (59 primary ovarian tumors and 24 extra-ovarian carcinomas) that were obtained from 68 ovarian carcinoma patients. Within the 59 primary tumors, 54 (92%) expressed immunoreactive TGFalpha, 45 (76%) expressed AR, and 28 (47%) expressed CR-1. The expression of AR and CR-1 mRNAs in the ovarian carcinomas was also demonstrated by RT-PCR analysis. Seventeen extra-ovarian specimens (71%) were found to express CR-1, whereas AR and TGFalpha were expressed respectively in 21 (87%) and 22 (92%) extra-ovarian tissues. In 15 cases for whom both ovarian and extra-ovarian tissues were available, a statistically significant higher expression of CR-1 was found in extra-ovarian specimens. A statistically significant correlation was found between AR expression in the ovarian carcinomas and both low grade and low proliferative activity. Finally, expression of TGFalpha was predictive of longer progression-free survival. These data strongly suggest that the EGF-related peptides might be involved in the pathogenesis and outcome of human ovarian cancer.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/GPI-Linked Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/TDGF1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor alpha,
http://linkedlifedata.com/resource/pubmed/chemical/amphiregulin
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1019-6439
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pubmed:author |
pubmed-author:BiancoCaterinaC,
pubmed-author:D'AntonioAntonioA,
pubmed-author:De LucaAntonellaA,
pubmed-author:GrassiMicheleM,
pubmed-author:GullickWilliam JWJ,
pubmed-author:IaffaioliVincenzo RVR,
pubmed-author:JohnsonGibbes RGR,
pubmed-author:LositoSimonaS,
pubmed-author:NormannoNicolaN,
pubmed-author:PerroneFrancescoF,
pubmed-author:PignataSandroS,
pubmed-author:SalomonDavid SDS,
pubmed-author:TambaroRosaR
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pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
941-8
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:12370739-Adult,
pubmed-meshheading:12370739-Aged,
pubmed-meshheading:12370739-Epidermal Growth Factor,
pubmed-meshheading:12370739-Female,
pubmed-meshheading:12370739-GPI-Linked Proteins,
pubmed-meshheading:12370739-Glycoproteins,
pubmed-meshheading:12370739-Humans,
pubmed-meshheading:12370739-Immunohistochemistry,
pubmed-meshheading:12370739-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:12370739-Membrane Glycoproteins,
pubmed-meshheading:12370739-Middle Aged,
pubmed-meshheading:12370739-Neoplasm Proteins,
pubmed-meshheading:12370739-Ovarian Neoplasms,
pubmed-meshheading:12370739-RNA, Messenger,
pubmed-meshheading:12370739-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:12370739-Transforming Growth Factor alpha
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pubmed:year |
2002
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pubmed:articleTitle |
Transforming growth factor alpha, amphiregulin and cripto-1 are frequently expressed in advanced human ovarian carcinomas.
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pubmed:affiliation |
Anatomia Patologica AORN Cardarelli, Naples, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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