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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
21
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pubmed:dateCreated |
2002-10-7
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pubmed:abstractText |
The isolation of a capsid intertypic poliovirus recombinant from a child with vaccine-associated paralytic poliomyelitis is described. Virus 31043 had a Sabin-derived type 3-type 2-type 1 recombinant genome with a 5'-end crossover point within the capsid coding region. The result was a poliovirus chimera containing the entire coding sequence for antigenic site 3a derived from the Sabin type 2 strain. The recombinant virus showed altered antigenic properties but did not acquire type 2 antigenic characteristics. The significance of the presence in nature of such poliovirus chimeras and the consequences for the current efforts to detect potentially dangerous vaccine-derived poliovirus strains are discussed in the context of the global polio eradication initiative.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12368335-10405373,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/12368335-8886095
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
76
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
10921-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12368335-Animals,
pubmed-meshheading:12368335-Antibodies, Viral,
pubmed-meshheading:12368335-Antigens, Viral,
pubmed-meshheading:12368335-Capsid,
pubmed-meshheading:12368335-Child, Preschool,
pubmed-meshheading:12368335-Crossing Over, Genetic,
pubmed-meshheading:12368335-Humans,
pubmed-meshheading:12368335-Male,
pubmed-meshheading:12368335-Mice,
pubmed-meshheading:12368335-Mice, Transgenic,
pubmed-meshheading:12368335-Neutralization Tests,
pubmed-meshheading:12368335-Paralysis,
pubmed-meshheading:12368335-Poliomyelitis,
pubmed-meshheading:12368335-Poliovirus,
pubmed-meshheading:12368335-Poliovirus Vaccine, Oral,
pubmed-meshheading:12368335-Sequence Analysis, DNA,
pubmed-meshheading:12368335-Temperature,
pubmed-meshheading:12368335-Tumor Cells, Cultured,
pubmed-meshheading:12368335-Virulence
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pubmed:year |
2002
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pubmed:articleTitle |
Isolation of an intertypic poliovirus capsid recombinant from a child with vaccine-associated paralytic poliomyelitis.
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pubmed:affiliation |
Division of Virology, National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, United Kingdom. jmartin@nibsc.ac.uk
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pubmed:publicationType |
Journal Article,
Case Reports
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