|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0007600,
umls-concept:C0033235,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0035696,
umls-concept:C0040690,
umls-concept:C0086597,
umls-concept:C0441889,
umls-concept:C0851285,
umls-concept:C1120843,
umls-concept:C1456820,
umls-concept:C1879647,
umls-concept:C2340138
|
|
pubmed:issue |
1-3
|
|
pubmed:dateCreated |
2002-9-25
|
|
pubmed:abstractText |
The role of members of the mitogen-activated protein kinase (MAPK) family on tumor necrosis factor alpha (TNF-alpha)-mediated down-regulation of col1a1 gene was studied. TNF-alpha increased extracellular-regulated kinase and Jun-N-terminal kinase phosphorylation, but these effects were not related to its inhibitory effect on alpha1(I) procollagen (col1a1) mRNA levels. Phosphorylation of p38 MAPK was decreased in response to TNF-alpha, and the specific p38 MAPK inhibitor SB203580 mimicked the effect of TNF-alpha on col1a1 mRNA levels. Transforming growth factor beta (TGF-beta) increased p38 MAPK phosphorylation and SB203580 prevented the induction of col1a1 mRNA levels by TGF-beta. These results suggest that p38 MAPK plays an important role in regulating the expression of col1a1 in hepatic stellate cells in response to cytokines.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Collagen Type I,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Imidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/SB 203580,
http://linkedlifedata.com/resource/pubmed/chemical/Sphingomyelin Phosphodiesterase,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0014-5793
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
25
|
|
pubmed:volume |
528
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
133-8
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:12297293-Animals,
pubmed-meshheading:12297293-Apoptosis,
pubmed-meshheading:12297293-Base Sequence,
pubmed-meshheading:12297293-Cell Line,
pubmed-meshheading:12297293-Collagen Type I,
pubmed-meshheading:12297293-Down-Regulation,
pubmed-meshheading:12297293-Enzyme Inhibitors,
pubmed-meshheading:12297293-Hepatocytes,
pubmed-meshheading:12297293-Imidazoles,
pubmed-meshheading:12297293-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:12297293-Mitogen-Activated Protein Kinases,
pubmed-meshheading:12297293-Phosphorylation,
pubmed-meshheading:12297293-Pyridines,
pubmed-meshheading:12297293-RNA, Messenger,
pubmed-meshheading:12297293-Rats,
pubmed-meshheading:12297293-Sphingomyelin Phosphodiesterase,
pubmed-meshheading:12297293-Transforming Growth Factor beta,
pubmed-meshheading:12297293-Tumor Necrosis Factor-alpha,
pubmed-meshheading:12297293-Up-Regulation,
pubmed-meshheading:12297293-p38 Mitogen-Activated Protein Kinases
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
p38 MAPK mediates the regulation of alpha1(I) procollagen mRNA levels by TNF-alpha and TGF-beta in a cell line of rat hepatic stellate cells(1).
|
|
pubmed:affiliation |
Department of Biochemistry, University of Navarra, C/Irunlarrea 1, 31008 Pamplona, Spain.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
