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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2002-9-18
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pubmed:abstractText |
Detrusor muscle invasive transitional cell carcinoma is associated with poor prognosis and is responsible for the majority of bladder cancer related deaths. Amplifications of c-myc and CCND1 are associated with detrusor-muscle-invasive transitional cell carcinoma, however, their precise role in driving disease progression is unclear. Fluorescence in situ hybridisation on archival tissue from 16 patients with primary diagnosis of > or = pT2 transitional cell carcinoma and 15 cases with primary pTa/pT1 disease subsequently progressing to detrusor-muscle-invasion was performed, in the latter group both pre and post muscle invasive events were studied. No patients presenting with >/=pT2 had amplification of c-myc, two out of 16 (12.5%) had CCND1 amplification. Of patients who developed > or = pT2, two out of 15 (13.3%) had amplification of c-myc, both in > or = pT2, five out of 15 (33.3%) had CCND1 amplification, two in pTa/pT1 tumours, three in > or = pT2 transitional cell carcinomas. In total, two out of 31 (6.5%) of patients' > or = pT2 TCCs were amplified for c-myc and six out of 31 (19%) were amplified for CCND1. Eighty-seven per cent (40 out of 46) of tumours were polysomic for chromosome 8 and 80% (37 out of 46) were polysomic for chromosome 11 and this reflected the high copy numbers of c-myc and CCND1 observed. In almost all cases an increase in c-myc/CCND1 copy number occurred prior to invasion and persisted in advanced disease. Amplification of CCND1 or alterations in c-myc/CCND1 early in bladder cancer may have clinical relevance in promoting and predicting progression to detrusor-muscle-invasive transitional cell carcinoma.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12237776-10197433,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12237776-10612290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12237776-11598453,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12237776-11745673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12237776-11747332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12237776-12142047,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12237776-7607576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12237776-7747807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12237776-8622895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12237776-9284824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12237776-9649132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12237776-9828832
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0007-0920
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
9
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pubmed:volume |
87
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
654-8
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pubmed:dateRevised |
2010-9-14
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pubmed:meshHeading |
pubmed-meshheading:12237776-Adult,
pubmed-meshheading:12237776-Aged,
pubmed-meshheading:12237776-Aged, 80 and over,
pubmed-meshheading:12237776-Carcinoma, Transitional Cell,
pubmed-meshheading:12237776-Chromosome Aberrations,
pubmed-meshheading:12237776-Chromosomes, Human, Pair 11,
pubmed-meshheading:12237776-Chromosomes, Human, Pair 8,
pubmed-meshheading:12237776-Cyclin D1,
pubmed-meshheading:12237776-DNA, Neoplasm,
pubmed-meshheading:12237776-Disease Progression,
pubmed-meshheading:12237776-Female,
pubmed-meshheading:12237776-Gene Amplification,
pubmed-meshheading:12237776-Genes, myc,
pubmed-meshheading:12237776-Humans,
pubmed-meshheading:12237776-In Situ Hybridization, Fluorescence,
pubmed-meshheading:12237776-Male,
pubmed-meshheading:12237776-Middle Aged,
pubmed-meshheading:12237776-Neoplasm Invasiveness,
pubmed-meshheading:12237776-Neoplasm Recurrence, Local,
pubmed-meshheading:12237776-Urinary Bladder Neoplasms
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pubmed:year |
2002
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pubmed:articleTitle |
Genetic aberrations of c-myc and CCND1 in the development of invasive bladder cancer.
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pubmed:affiliation |
University Department of Surgery, Level II, Queen Elizabeth Building, Glasgow Royal Infirmary, Glasgow G31 2ER, UK.
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pubmed:publicationType |
Journal Article
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