Resistance to linezolid has been associated with a G2576U mutation in domain V of the 23S rRNA. We analyzed nine clinical isolates of linezolid-resistant enterococci and showed a clear association between the number of 23S rRNA genes containing this mutation and the level of linezolid resistance expressed.
Research and Medical Services, Department of Veterans Affairs Medical Center and Division of Infectious Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.