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pubmed:abstractText |
Although apoptosis has been linked to the renal cell deletion and ensuing renal fibrosis, its regulating mechanisms remain obscure. Of the known regulators of apoptosis, the best characterized is the Bax to Bcl-2 ratio. However, its importance in controlling apoptosis in glomerulonephritis is unclear. Here, using the nephrotoxic nephritis (NTN) model, we evaluated Bax/Bcl-2 in relation to changes in the apoptosis co-ordination enzyme, caspase-3.
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pubmed:affiliation |
Sheffield Kidney Institute, Division of Clinical Sciences, Department of Histopathology, Northern General Hospital Trust, Sheffield University, Herries Road, Sheffield, England S5 7AU, UK.
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