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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-3
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pubmed:dateCreated |
2002-9-10
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pubmed:abstractText |
We report a study on the regulation by 2-chloro adenosine (2CA) of a glutamate (Glu) transporter in myogenic C2C12 cells. Long-term 2CA exposition significantly increased the V(max) of the Glu transporter. Moreover, 2CA-treated cells responded to Glu challenge by a rapid and transient increase in their intracellular calcium level. The above reported effects were totally abolished by treating C2C12 cells with the Na(+)-dependent Glu transporter inhibitors DL-threo-b-hydroxyaspartic acid and L-trans-pyrrolidine-2,4-dicarboxylic acid. We propose that the possible link between the Glu uptake increase and the Glu induction of calcium rise could be the depolarizing currents carried by Na(+) coupled with transporter activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-Chloroadenosine,
http://linkedlifedata.com/resource/pubmed/chemical/3-hydroxyaspartic acid,
http://linkedlifedata.com/resource/pubmed/chemical/Amino Acid Transport System X-AG,
http://linkedlifedata.com/resource/pubmed/chemical/Aspartic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Cycloheximide,
http://linkedlifedata.com/resource/pubmed/chemical/Dicarboxylic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamate Plasma Membrane...,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Synthesis Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Purines,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrrolidines,
http://linkedlifedata.com/resource/pubmed/chemical/Symporters,
http://linkedlifedata.com/resource/pubmed/chemical/pyrrolidine-2,4-dicarboxylic acid
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
527
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
269-73
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12220672-2-Chloroadenosine,
pubmed-meshheading:12220672-Amino Acid Transport System X-AG,
pubmed-meshheading:12220672-Animals,
pubmed-meshheading:12220672-Aspartic Acid,
pubmed-meshheading:12220672-Biological Transport,
pubmed-meshheading:12220672-Calcium,
pubmed-meshheading:12220672-Cell Differentiation,
pubmed-meshheading:12220672-Cells, Cultured,
pubmed-meshheading:12220672-Cycloheximide,
pubmed-meshheading:12220672-Dicarboxylic Acids,
pubmed-meshheading:12220672-Glutamate Plasma Membrane Transport Proteins,
pubmed-meshheading:12220672-Glutamic Acid,
pubmed-meshheading:12220672-Mice,
pubmed-meshheading:12220672-Muscle, Skeletal,
pubmed-meshheading:12220672-Muscle Fibers, Skeletal,
pubmed-meshheading:12220672-Protein Synthesis Inhibitors,
pubmed-meshheading:12220672-Purines,
pubmed-meshheading:12220672-Pyrrolidines,
pubmed-meshheading:12220672-Symporters,
pubmed-meshheading:12220672-Up-Regulation
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pubmed:year |
2002
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pubmed:articleTitle |
Glutamate-induced calcium increase in myotubes depends on up-regulation of a sodium-dependent transporter.
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pubmed:affiliation |
Department of Pharmacology, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.
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pubmed:publicationType |
Journal Article
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