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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2002-9-9
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pubmed:abstractText |
MYCN (N-myc) amplification in neuroblastoma is associated with poor clinical outcome. Factors that regulate MYCN expression have not been elucidated. MYCN is considered a TATA-less promoter, whereas significant promoter activity resides within 160 bp 5' of the major transcription start site. This region contains two GC-rich motifs and a CT box, regions for potential transcription factor interaction.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0039-6060
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
132
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
232-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12219017-Base Sequence,
pubmed-meshheading:12219017-Binding Sites,
pubmed-meshheading:12219017-Consensus Sequence,
pubmed-meshheading:12219017-Electrophoretic Mobility Shift Assay,
pubmed-meshheading:12219017-GC Rich Sequence,
pubmed-meshheading:12219017-Gene Expression Regulation,
pubmed-meshheading:12219017-HeLa Cells,
pubmed-meshheading:12219017-Humans,
pubmed-meshheading:12219017-Molecular Sequence Data,
pubmed-meshheading:12219017-Nuclear Proteins,
pubmed-meshheading:12219017-Oncogene Proteins,
pubmed-meshheading:12219017-Promoter Regions, Genetic,
pubmed-meshheading:12219017-Sp1 Transcription Factor
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pubmed:year |
2002
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pubmed:articleTitle |
Importance of Sp1 consensus motifs in the MYCN promoter.
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pubmed:affiliation |
Children's Hospital Research Foundation and Department of Pediatric Surgery, Cincinnati Children's Hospital Medical Center, Ohio 45229,USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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