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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2002-8-15
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pubmed:abstractText |
A small proportion of patients with chronic myeloproliferative diseases have constitutive activation of the gene for platelet-derived growth factor receptor beta (PDGFRB), which encodes a receptor tyrosine kinase. The gene is located on chromosome 5q33, and the activation is usually caused by a t(5;12)(q33;p13) translocation associated with an ETV6-PDGFRB fusion gene. The tyrosine kinase inhibitor imatinib mesylate specifically inhibits ABL, PDGFR, and KIT kinases and has impressive clinical efficacy in BCR-ABL-positive chronic myeloid leukemia.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ETS translocation variant 6 protein,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins, Fusion,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-ets,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Platelet-Derived Growth...,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/imatinib
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1533-4406
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pubmed:author |
pubmed-author:ApperleyJane FJF,
pubmed-author:BainBarbara JBJ,
pubmed-author:BaxterE JoannaEJ,
pubmed-author:ChaseAndrewA,
pubmed-author:ChessellsJudith MJM,
pubmed-author:ColombatMarieM,
pubmed-author:CrossNicholas C PNC,
pubmed-author:DeardenClaire ECE,
pubmed-author:DimitrijevicSasaS,
pubmed-author:GardembasMartineM,
pubmed-author:GoldmanJohn MJM,
pubmed-author:MahonFrançois-XFX,
pubmed-author:MarinDavidD,
pubmed-author:MeloJunia VJV,
pubmed-author:NikolovaZarianaZ,
pubmed-author:OlavarriaEduardoE,
pubmed-author:Russell-JonesRobinR,
pubmed-author:SchultheisBeateB,
pubmed-author:SilbermanSandraS
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pubmed:copyrightInfo |
Copyright 2002 Massachusetts Medical Society
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
347
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
481-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12181402-Adult,
pubmed-meshheading:12181402-Aged,
pubmed-meshheading:12181402-Child,
pubmed-meshheading:12181402-Chromosomes, Human, Pair 5,
pubmed-meshheading:12181402-DNA-Binding Proteins,
pubmed-meshheading:12181402-Eosinophilia,
pubmed-meshheading:12181402-Gene Rearrangement,
pubmed-meshheading:12181402-Humans,
pubmed-meshheading:12181402-In Situ Hybridization, Fluorescence,
pubmed-meshheading:12181402-Leukocytosis,
pubmed-meshheading:12181402-Male,
pubmed-meshheading:12181402-Middle Aged,
pubmed-meshheading:12181402-Myeloproliferative Disorders,
pubmed-meshheading:12181402-Oncogene Proteins, Fusion,
pubmed-meshheading:12181402-Piperazines,
pubmed-meshheading:12181402-Protein-Tyrosine Kinases,
pubmed-meshheading:12181402-Proto-Oncogene Proteins c-ets,
pubmed-meshheading:12181402-Pyrimidines,
pubmed-meshheading:12181402-Receptor, Platelet-Derived Growth Factor beta,
pubmed-meshheading:12181402-Repressor Proteins
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pubmed:year |
2002
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pubmed:articleTitle |
Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta.
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pubmed:affiliation |
Department of Haematology, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom. j.apperley@ic.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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