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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2002-8-14
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pubmed:abstractText |
Spatially and temporally regulated activity of Branchless/Breathless signaling is essential for trachea development in Drosophila. Early ubiquitous breathless (btl) expression is controlled by binding of Trachealess/Tango heterodimers to the btl minimum enhancer. Branchless/Breathless signaling includes a Sprouty-dependent negative feedback loop. We show that late btl expression is a target of Branchless/Breathless signaling and hence, Branchless/Breathless signaling contains a positive feedback loop, which may guarantee a continuous supply of fresh receptors to membranes of growing tracheal branch cells. Branchless/Breathless signaling activates MAP-kinase, which in turn, activates late btl expression and destabilizes Anterior-open, a repressor for late btl expression. Biochemical and genetic analysis indicated that the minimum btl enhancer includes binding sites of Anterior-open.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Eye Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/RNA,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Fibroblast Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/anterior open protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/breathless protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0925-4773
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2002 Elsevier Science Ireland Ltd.
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pubmed:issnType |
Print
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pubmed:volume |
114
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3-11
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12175485-Animals,
pubmed-meshheading:12175485-Base Sequence,
pubmed-meshheading:12175485-Drosophila,
pubmed-meshheading:12175485-Drosophila Proteins,
pubmed-meshheading:12175485-Eye Proteins,
pubmed-meshheading:12175485-Gene Expression Regulation, Developmental,
pubmed-meshheading:12175485-Immunohistochemistry,
pubmed-meshheading:12175485-Ligands,
pubmed-meshheading:12175485-MAP Kinase Signaling System,
pubmed-meshheading:12175485-Models, Genetic,
pubmed-meshheading:12175485-Molecular Sequence Data,
pubmed-meshheading:12175485-Mutagenesis,
pubmed-meshheading:12175485-Plasmids,
pubmed-meshheading:12175485-Polymerase Chain Reaction,
pubmed-meshheading:12175485-Protein-Tyrosine Kinases,
pubmed-meshheading:12175485-RNA,
pubmed-meshheading:12175485-Receptors, Fibroblast Growth Factor,
pubmed-meshheading:12175485-Repressor Proteins,
pubmed-meshheading:12175485-Signal Transduction,
pubmed-meshheading:12175485-Trachea,
pubmed-meshheading:12175485-Transcription, Genetic
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pubmed:year |
2002
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pubmed:articleTitle |
Ligand-dependent activation of breathless FGF receptor gene in Drosophila developing trachea.
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pubmed:affiliation |
Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, 7-3-1 Hongo, Bunkyou-ku, Tokyo 113-0033, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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