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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2002-8-12
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pubmed:abstractText |
Natural killer (NK) cells have been identified in human vascular pathologies. In this study, we identified NK cells in aortic root atherosclerotic lesions of low density lipoprotein (LDL) receptor-deficient (LDLr-/-) mice. To characterize the role of NK cell-mediated cytolysis in atherosclerosis, we generated C57Bl/6 double-mutant mice by crossing LDLr-/- mice with NK cell-defective Lyst(beige) mice (creating beige,LDLr-/- mice) and with perforin-deficient mice (creating Pfp-/-,LDLr-/- mice).
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1524-4636
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1341-6
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:12171798-Animals,
pubmed-meshheading:12171798-Aorta,
pubmed-meshheading:12171798-Arteriosclerosis,
pubmed-meshheading:12171798-Inflammation,
pubmed-meshheading:12171798-Killer Cells, Natural,
pubmed-meshheading:12171798-Male,
pubmed-meshheading:12171798-Membrane Glycoproteins,
pubmed-meshheading:12171798-Mice,
pubmed-meshheading:12171798-Mice, Inbred C57BL,
pubmed-meshheading:12171798-Mice, Mutant Strains,
pubmed-meshheading:12171798-Perforin,
pubmed-meshheading:12171798-Pore Forming Cytotoxic Proteins,
pubmed-meshheading:12171798-Proteins,
pubmed-meshheading:12171798-Receptors, LDL
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pubmed:year |
2002
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pubmed:articleTitle |
Inflammation in atherosclerosis: lesion formation in LDL receptor-deficient mice with perforin and Lyst(beige) mutations.
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pubmed:affiliation |
Scripps Research Institute, Department of Immunology, La Jolla, Calif., USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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