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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2002-8-6
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pubmed:abstractText |
The purpose of this study was to evaluate the effect of coadministration of macrophage colony-stimulating factor (M-CSF) and interferon-alpha (IFN-alpha) on NK1.1(+) cells in mice. Administration of M-CSF, but not IFN-alpha, increased the number of NK1.1(+) cells and CD11b(+) cells in spleen and blood. Coadministration of the two agents induced a greater increase in NK1.1(+) cells than did administration of M-CSF alone. Administration of M-CSF or IFN-alpha augmented the clearance activity of Yac-1 cells in lung, and coadministration of these agents further augmented this effect. The combination of M-CSF and IFN-alpha effectively reduced the formation of tumor nodules in lung and liver in an experimental metastasis model using B16 melanoma. The combination of M-CSF and IFN-alpha induced the increase and activation of NK1.1(+) cells more than either agent alone. These effects may contribute to the antimetastatic reaction by NK1.1(+) cells in vivo.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1079-9907
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
701-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12162882-Animals,
pubmed-meshheading:12162882-Antigens, CD11b,
pubmed-meshheading:12162882-Antigens, CD11c,
pubmed-meshheading:12162882-Antigens, CD3,
pubmed-meshheading:12162882-Drug Synergism,
pubmed-meshheading:12162882-Drug Therapy, Combination,
pubmed-meshheading:12162882-Humans,
pubmed-meshheading:12162882-Interferon-alpha,
pubmed-meshheading:12162882-Killer Cells, Natural,
pubmed-meshheading:12162882-Liver Neoplasms,
pubmed-meshheading:12162882-Lung Neoplasms,
pubmed-meshheading:12162882-Lymphocyte Activation,
pubmed-meshheading:12162882-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:12162882-Male,
pubmed-meshheading:12162882-Melanoma, Experimental,
pubmed-meshheading:12162882-Mice,
pubmed-meshheading:12162882-Mice, Inbred C57BL,
pubmed-meshheading:12162882-Recombinant Proteins,
pubmed-meshheading:12162882-Spleen
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pubmed:year |
2002
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pubmed:articleTitle |
Effect of coadministration of M-CSF and IFN-alpha on NK1.1+ cells in mice.
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pubmed:affiliation |
Biochemical Research Laboratory, Morinaga Milk Industry Co., Ltd., 5-Chome Higashihara Zama-city, Kanagawa pref., Japan. takuma-s@po.iijnet.or.jp
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pubmed:publicationType |
Journal Article,
Comparative Study,
Evaluation Studies
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