Source:http://linkedlifedata.com/resource/pubmed/id/12151774
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
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| pubmed:dateCreated |
2002-8-1
|
| pubmed:abstractText |
Treatment with an antagonist at the neurokinin-1 (NK-1) receptor may alleviate depression, however the brain region(s) in which the NK-1 receptor antagonist exerts its therapeutic effect is unknown. [125I]BH-Substance P was used to measure NK-1 receptors postmortem in cytoarchitectonically defined areas of rostral orbitofrontal cortex (Brodmann's area 47) of subjects with major depressive disorder (n = 12, six females) and psychiatrically normal subjects (n = 11, five females). Six subjects with depression died by suicide. Subjects with depression showed decreased binding to NK-1 receptors across all cortical layers (p = 0.024). The pathophysiology of depression, and the reported therapeutic benefit of NK-1 receptor antagonists, may thus involve NK-1 receptors in prefrontal cortex.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0959-4965
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
2
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1223-7
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:12151774-Adult,
pubmed-meshheading:12151774-Age Factors,
pubmed-meshheading:12151774-Aged,
pubmed-meshheading:12151774-Aged, 80 and over,
pubmed-meshheading:12151774-Binding, Competitive,
pubmed-meshheading:12151774-Binding Sites,
pubmed-meshheading:12151774-Brain Chemistry,
pubmed-meshheading:12151774-Depressive Disorder, Major,
pubmed-meshheading:12151774-Down-Regulation,
pubmed-meshheading:12151774-Female,
pubmed-meshheading:12151774-Humans,
pubmed-meshheading:12151774-Male,
pubmed-meshheading:12151774-Middle Aged,
pubmed-meshheading:12151774-Neurons,
pubmed-meshheading:12151774-Prefrontal Cortex,
pubmed-meshheading:12151774-Radioligand Assay,
pubmed-meshheading:12151774-Receptors, Neurokinin-1,
pubmed-meshheading:12151774-Substance P,
pubmed-meshheading:12151774-Suicide
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Neurokinin-1 receptors are decreased in major depressive disorder.
|
| pubmed:affiliation |
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 North State Street, Jackson 39216, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|