Linked Life Data

12137754

Source:http://linkedlifedata.com/resource/pubmed/id/12137754

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2002-7-24
pubmed:abstractText
Analysis of osmotic water permeability of aquaporin (AQP) 1, AQP3 and AQP4, which are expressed in human small intestine, in the presence or absence of cholera toxin (CT) was performed using a Xenopus oocyte expression system. When treated with CT, water permeability of AQP4 was facilitated while that of AQP3 was suppressed. AQP1 did not show any significant change of water permeability when treated with CT. An adenylyl cyclase accelerator forskolin showed similar effects as CT did, suggesting that changes of the water permeability of AQP4 and AQP3 were due to an increase of intracellular cAMP concentration. A possibility that these AQPs are responsible molecules for causing acute secretory diarrhoea as in cholera is considered.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0882-4010
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
273-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Positive and negative regulation of water channel aquaporins in human small intestine by cholera toxin.
pubmed:affiliation
Research Institute, International Medical Center of Japan, Tokyo 162-8655, Japan. thama@ri.imcj.go.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't