|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2002-7-18
|
|
pubmed:abstractText |
In the brains of Alzheimer's disease (AD) patients, microglia cells are activated and produce inflammatory mediators such as tumor necrosis factor-alpha (TNF-alpha). A recent study conducted in Northern Ireland showed that a polymorphism in the promotor region (-850) of the TNF-alpha gene increased the risk of AD associated with carriage of the apolipoprotein E (APOE) epsilon 4 allele. In a case-control study restricted to a population from Northern Spain and utilizing 321 sporadic AD patients and 312 control subjects, we have found that the -850 TNF-alpha polymorphism does not interact with the APOE gene to increase the risk associated with the epsilon 4 allele.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0304-3940
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
2
|
|
pubmed:volume |
328
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
71-3
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:12123862-Age of Onset,
pubmed-meshheading:12123862-Aged,
pubmed-meshheading:12123862-Aged, 80 and over,
pubmed-meshheading:12123862-Alzheimer Disease,
pubmed-meshheading:12123862-Apolipoprotein E4,
pubmed-meshheading:12123862-Apolipoproteins E,
pubmed-meshheading:12123862-Case-Control Studies,
pubmed-meshheading:12123862-DNA Mutational Analysis,
pubmed-meshheading:12123862-Encephalitis,
pubmed-meshheading:12123862-Female,
pubmed-meshheading:12123862-Gene Frequency,
pubmed-meshheading:12123862-Genetic Predisposition to Disease,
pubmed-meshheading:12123862-Genetic Testing,
pubmed-meshheading:12123862-Genotype,
pubmed-meshheading:12123862-Humans,
pubmed-meshheading:12123862-Inflammation Mediators,
pubmed-meshheading:12123862-Male,
pubmed-meshheading:12123862-Microglia,
pubmed-meshheading:12123862-Middle Aged,
pubmed-meshheading:12123862-Polymorphism, Genetic,
pubmed-meshheading:12123862-Promoter Regions, Genetic,
pubmed-meshheading:12123862-Risk Factors,
pubmed-meshheading:12123862-Spain,
pubmed-meshheading:12123862-Tumor Necrosis Factor-alpha
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
No synergistic effect between -850 tumor necrosis factor-alpha promoter polymorphism and apolipoprotein E epsilon 4 allele in Alzheimer's disease.
|
|
pubmed:affiliation |
Service of Neurology, University Hospital Marqués de Valdecilla, University of Cantabria, 39008 Santander, Spain.
|
|
pubmed:publicationType |
Journal Article
|
