Linked Life Data

12119391

Source:http://linkedlifedata.com/resource/pubmed/id/12119391

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
15
pubmed:dateCreated
2002-7-24
pubmed:abstractText
Optical coherence tomography (OCT) is a rapidly emerging technology for high-resolution biomedical imaging. The axial resolution of this technology is determined by the bandwidth of the source. Commercial sources generally provide resolutions of 10-20 microm whereas laboratory-based solid state lasers have resolutions of approximately 4 microm. The resolution in tissue depends almost exclusively on detecting single scattered events. However, the phenomenon known as multiple scattering results in a deterioration of resolution as a function of depth. In this study, OCT was combined with ultrasound in an attempt to reduce the effect of multiple scattering. The theory is that, with parallel ultrasound and OCT beams, multiply scattered light with a momentum component significantly perpendicular to the OCT beam will be reduced because the light is Doppler shifted outside the bandpass filter of the OCT detection electronics. A 7.5-MHz ultrasound transducer was used to introduce the photon/phonon interaction. A reflecting metal plate was placed within biological tissue, and the point spread function (PSF) was assessed off the reflector. The PSF was determined in the presence of no ultrasound, pulsed ultrasound, and continuous-wave (CW) ultrasound. CW ultrasound resulted in a 17% improvement (P < 0.001) in resolution and pulsed ultrasound resulted in 8% (P < 0.01). Image noise reduction could also be noted. Combining OCT with a parallel ultrasound beam results in an improvement in resolution through a reduced effect of multiple scattering due to photon/phonon interaction. With higher frequencies, better control of the acoustical beam, and tests in media with higher rates of multiple scattering, improved results are anticipated.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12119391-10090174, http://linkedlifedata.com/resource/pubmed/commentcorrection/12119391-11409125, http://linkedlifedata.com/resource/pubmed/commentcorrection/12119391-11461618, http://linkedlifedata.com/resource/pubmed/commentcorrection/12119391-1957169, http://linkedlifedata.com/resource/pubmed/commentcorrection/12119391-1962353, http://linkedlifedata.com/resource/pubmed/commentcorrection/12119391-8481244, http://linkedlifedata.com/resource/pubmed/commentcorrection/12119391-8653843, http://linkedlifedata.com/resource/pubmed/commentcorrection/12119391-9196405, http://linkedlifedata.com/resource/pubmed/commentcorrection/12119391-9197265, http://linkedlifedata.com/resource/pubmed/commentcorrection/12119391-9271275, http://linkedlifedata.com/resource/pubmed/commentcorrection/12119391-9916971
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
23
pubmed:volume
99
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
9761-4
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Ultrasound induced improvement in optical coherence tomography (OCT) resolution.
pubmed:affiliation
Department of Orthopedics Research, Brigham and Women's Hospital, Boston, MA 02115, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.