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rdf:type |
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lifeskim:mentions |
umls-concept:C0013081,
umls-concept:C0030705,
umls-concept:C0033268,
umls-concept:C0036098,
umls-concept:C0039082,
umls-concept:C0055082,
umls-concept:C0086418,
umls-concept:C0165519,
umls-concept:C0301625,
umls-concept:C0304231,
umls-concept:C0521447,
umls-concept:C0596030,
umls-concept:C0678594,
umls-concept:C1261381,
umls-concept:C1292733,
umls-concept:C1456820,
umls-concept:C1521761,
umls-concept:C1709305
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pubmed:issue |
6
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pubmed:dateCreated |
2002-7-12
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pubmed:abstractText |
Our previous results suggested that suppression of tumor necrosis factor alpha (TNFalpha)-induced matrix metalloproteinase 9 (MMP-9) could prevent the destruction of acinar tissue in the salivary glands of patients with Sjögren's syndrome (SS). The present study was undertaken to investigate the effect of cepharanthine on the suppression of TNFalpha-induced MMP-9 production in NS-SV-AC, an SV40-immortalized normal human acinar cell clone.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alkaloids,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents...,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Benzylisoquinolines,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen Type II,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/I-kappa B Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 9,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappaB inhibitor alpha,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/cepharanthine
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1585-94
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12115190-Alkaloids,
pubmed-meshheading:12115190-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:12115190-Antibodies,
pubmed-meshheading:12115190-Benzylisoquinolines,
pubmed-meshheading:12115190-Cell Division,
pubmed-meshheading:12115190-Cells, Cultured,
pubmed-meshheading:12115190-Collagen Type II,
pubmed-meshheading:12115190-DNA-Binding Proteins,
pubmed-meshheading:12115190-Down-Regulation,
pubmed-meshheading:12115190-Enzyme Activation,
pubmed-meshheading:12115190-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:12115190-Humans,
pubmed-meshheading:12115190-I-kappa B Proteins,
pubmed-meshheading:12115190-Matrix Metalloproteinase 9,
pubmed-meshheading:12115190-NF-kappa B,
pubmed-meshheading:12115190-Promoter Regions, Genetic,
pubmed-meshheading:12115190-RNA, Messenger,
pubmed-meshheading:12115190-Salivary Glands,
pubmed-meshheading:12115190-Tumor Necrosis Factor-alpha
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pubmed:year |
2002
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pubmed:articleTitle |
Suppression of tumor necrosis factor alpha-induced matrix metalloproteinase 9 production in human salivary gland acinar cells by cepharanthine occurs via down-regulation of nuclear factor kappaB: a possible therapeutic agent for preventing the destruction of the acinar structure in the salivary glands of Sjögren's syndrome patients.
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pubmed:affiliation |
Department of Oral and Maxillofacial Surgery 2, Tokushima University School of Dentistry, 3 Kuramoto-cho, Tokushima 770-8504, Japan. azumasa@dent.tokushima-u.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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