rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5578
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pubmed:dateCreated |
2002-7-5
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pubmed:abstractText |
Drosophila host defense to fungal and Gram-positive bacterial infection is mediated by the Spaetzle/Toll/cactus gene cassette. It has been proposed that Toll does not function as a pattern recognition receptor per se but is activated through a cleaved form of the cytokine Spaetzle. The upstream events linking infection to the cleavage of Spaetzle have long remained elusive. Here we report the identification of a central component of the fungal activation of Toll. We show that ethylmethane sulfonate-induced mutations in the persephone gene, which encodes a previously unknown serine protease, block induction of the Toll pathway by fungi and resistance to this type of infection.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Insect Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Sorting Signals,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Serine Endopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/Tl protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptors,
http://linkedlifedata.com/resource/pubmed/chemical/drosomycin protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/spatzle protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
5
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pubmed:volume |
297
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
114-6
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pubmed:dateRevised |
2008-10-15
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pubmed:meshHeading |
pubmed-meshheading:12098703-Amino Acid Sequence,
pubmed-meshheading:12098703-Animals,
pubmed-meshheading:12098703-Chromosome Mapping,
pubmed-meshheading:12098703-Drosophila,
pubmed-meshheading:12098703-Drosophila Proteins,
pubmed-meshheading:12098703-Escherichia coli,
pubmed-meshheading:12098703-Female,
pubmed-meshheading:12098703-Gene Expression Regulation,
pubmed-meshheading:12098703-Genes, Insect,
pubmed-meshheading:12098703-Gram-Positive Cocci,
pubmed-meshheading:12098703-Hemolymph,
pubmed-meshheading:12098703-Hypocreales,
pubmed-meshheading:12098703-Insect Proteins,
pubmed-meshheading:12098703-Male,
pubmed-meshheading:12098703-Molecular Sequence Data,
pubmed-meshheading:12098703-Mutation,
pubmed-meshheading:12098703-Protein Sorting Signals,
pubmed-meshheading:12098703-Protein Structure, Tertiary,
pubmed-meshheading:12098703-Receptors, Cell Surface,
pubmed-meshheading:12098703-Serine Endopeptidases,
pubmed-meshheading:12098703-Toll-Like Receptors
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pubmed:year |
2002
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pubmed:articleTitle |
Activation of Drosophila Toll during fungal infection by a blood serine protease.
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pubmed:affiliation |
Institut de Biologie Moléculaire et Cellulaire, UPR 9022 du CNRS, 15 rue R. Descartes, F67084 Strasbourg Cedex, France.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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