Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5578
pubmed:dateCreated
2002-7-5
pubmed:abstractText
Drosophila host defense to fungal and Gram-positive bacterial infection is mediated by the Spaetzle/Toll/cactus gene cassette. It has been proposed that Toll does not function as a pattern recognition receptor per se but is activated through a cleaved form of the cytokine Spaetzle. The upstream events linking infection to the cleavage of Spaetzle have long remained elusive. Here we report the identification of a central component of the fungal activation of Toll. We show that ethylmethane sulfonate-induced mutations in the persephone gene, which encodes a previously unknown serine protease, block induction of the Toll pathway by fungi and resistance to this type of infection.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1095-9203
pubmed:author
pubmed:issnType
Electronic
pubmed:day
5
pubmed:volume
297
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
114-6
pubmed:dateRevised
2008-10-15
pubmed:meshHeading
pubmed-meshheading:12098703-Amino Acid Sequence, pubmed-meshheading:12098703-Animals, pubmed-meshheading:12098703-Chromosome Mapping, pubmed-meshheading:12098703-Drosophila, pubmed-meshheading:12098703-Drosophila Proteins, pubmed-meshheading:12098703-Escherichia coli, pubmed-meshheading:12098703-Female, pubmed-meshheading:12098703-Gene Expression Regulation, pubmed-meshheading:12098703-Genes, Insect, pubmed-meshheading:12098703-Gram-Positive Cocci, pubmed-meshheading:12098703-Hemolymph, pubmed-meshheading:12098703-Hypocreales, pubmed-meshheading:12098703-Insect Proteins, pubmed-meshheading:12098703-Male, pubmed-meshheading:12098703-Molecular Sequence Data, pubmed-meshheading:12098703-Mutation, pubmed-meshheading:12098703-Protein Sorting Signals, pubmed-meshheading:12098703-Protein Structure, Tertiary, pubmed-meshheading:12098703-Receptors, Cell Surface, pubmed-meshheading:12098703-Serine Endopeptidases, pubmed-meshheading:12098703-Toll-Like Receptors
pubmed:year
2002
pubmed:articleTitle
Activation of Drosophila Toll during fungal infection by a blood serine protease.
pubmed:affiliation
Institut de Biologie Moléculaire et Cellulaire, UPR 9022 du CNRS, 15 rue R. Descartes, F67084 Strasbourg Cedex, France.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't