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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2002-6-27
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pubmed:abstractText |
Electrical silencing of Drosophila circadian pacemaker neurons through targeted expression of K+ channels causes severe deficits in free-running circadian locomotor rhythmicity in complete darkness. Pacemaker electrical silencing also stops the free-running oscillation of PERIOD (PER) and TIMELESS (TIM) proteins that constitutes the core of the cell-autonomous molecular clock. In contrast, electrical silencing fails to abolish PER and TIM oscillation in light-dark cycles, although it does impair rhythmic behavior. On the basis of these findings, we propose that electrical activity is an essential element of the free-running molecular clock of pacemaker neurons along with the transcription factors and regulatory enzymes that have been previously identified as required for clock function.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Insect Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ork1 protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/PER protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/Period Circadian Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels, Inwardly...,
http://linkedlifedata.com/resource/pubmed/chemical/timeless protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
109
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
485-95
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12086605-Action Potentials,
pubmed-meshheading:12086605-Animals,
pubmed-meshheading:12086605-Biological Clocks,
pubmed-meshheading:12086605-Cell Size,
pubmed-meshheading:12086605-Circadian Rhythm,
pubmed-meshheading:12086605-Dark Adaptation,
pubmed-meshheading:12086605-Drosophila Proteins,
pubmed-meshheading:12086605-Drosophila melanogaster,
pubmed-meshheading:12086605-Gene Expression Regulation, Developmental,
pubmed-meshheading:12086605-Genes, Lethal,
pubmed-meshheading:12086605-Insect Proteins,
pubmed-meshheading:12086605-Motor Activity,
pubmed-meshheading:12086605-Mutation,
pubmed-meshheading:12086605-Nervous System,
pubmed-meshheading:12086605-Neurons,
pubmed-meshheading:12086605-Nuclear Proteins,
pubmed-meshheading:12086605-Period Circadian Proteins,
pubmed-meshheading:12086605-Photic Stimulation,
pubmed-meshheading:12086605-Potassium Channels,
pubmed-meshheading:12086605-Potassium Channels, Inwardly Rectifying,
pubmed-meshheading:12086605-Synapses,
pubmed-meshheading:12086605-Synaptic Transmission
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pubmed:year |
2002
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pubmed:articleTitle |
Electrical silencing of Drosophila pacemaker neurons stops the free-running circadian clock.
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pubmed:affiliation |
Department of Biology, New York University, New York 10003, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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