Source:http://linkedlifedata.com/resource/pubmed/id/12086404
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2002-6-27
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| pubmed:abstractText |
It is well accepted that an increase in the expression of cyclooxygenase-2 (COX-2), a key inducible enzyme involved in the production of prostaglandins and other eicosanoids, may play a significant role in carcinogenesis in addition to its well-known role in inflammatory reactions. Whereas previous studies were largely confined to colorectal tumorigenesis, we have shown that a significantly increased expression of COX-2 may also play a role in the development of lung cancer. COX-2 expression was found to be frequently elevated in lung cancer, especially in adenocarcinoma, and the proportion of lung cancer cells with marked COX-2 expression was much higher in lymph node metastases than in the corresponding primary tumors. It was also shown that early stage adenocarcinoma patients with increased COX-2 expression who were surgically treated had a shorter survival. Our studies, which used high- and low-metastatic human lung cancer cell sublines established in our laboratory, revealed an association between metastatic capabilities and COX-2 expression levels: COX-2-specific inhibitors could inhibit in vitro the invasion of the highly metastatic NCI-H460-LNM35 clone through Matrigel-containing basement membrane components as well as the spontaneous in vivo metastasis in SCID mice. Taken together, these findings suggest that an increase in COX-2 expression maybe associated with the development of lung cancer and possibly with the acquisition of an invasive and metastatic phenotype.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2 Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PTGS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases
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| pubmed:status |
MEDLINE
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| pubmed:issn |
0731-8898
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
21
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
177-81
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12086404-Adenocarcinoma,
pubmed-meshheading:12086404-Animals,
pubmed-meshheading:12086404-Cyclooxygenase 2,
pubmed-meshheading:12086404-Cyclooxygenase 2 Inhibitors,
pubmed-meshheading:12086404-Cyclooxygenase Inhibitors,
pubmed-meshheading:12086404-Humans,
pubmed-meshheading:12086404-Isoenzymes,
pubmed-meshheading:12086404-Lung Neoplasms,
pubmed-meshheading:12086404-Membrane Proteins,
pubmed-meshheading:12086404-Mice,
pubmed-meshheading:12086404-Mice, SCID,
pubmed-meshheading:12086404-Neoplasm Invasiveness,
pubmed-meshheading:12086404-Neoplasm Metastasis,
pubmed-meshheading:12086404-Neoplasm Staging,
pubmed-meshheading:12086404-Phenotype,
pubmed-meshheading:12086404-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:12086404-Survival Analysis,
pubmed-meshheading:12086404-Tumor Cells, Cultured
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| pubmed:year |
2002
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| pubmed:articleTitle |
Increased expression of COX-2 in the development of human lung cancers.
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| pubmed:affiliation |
Division of Molecular Oncology, Aichi Cancer Center Research Institute, Nagoya, Japan. tak@aichi-cc.pref.aichi.jp
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|