Linked Life Data

12070616

Source:http://linkedlifedata.com/resource/pubmed/id/12070616

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2002-6-18
pubmed:abstractText
The kuzbanian gene encodes a metalloprotease of the ADAM family that is involved in Notch signalling. However, its precise role is a matter of controversy. While original reports concluded that kuz is required on the receiving side of the Notch signalling pathway, a more recent report suggests that Kuz is required on the signal-emitting side for the generation of an active secreted form of the ligand Delta. In this scenario, kuz should act cell non-autonomously. A third possibility is that Kuz is required on the signal-emitting as well as the receiving side. Here I present the clonal analysis of kuz in Drosophila wing. The results show that Kuz acts on the receiving side of the pathway and is not required for Delta signalling. This further confirms the hypothesis that Kuz is required for the release of the intracellular domain of Notch that transduces the signal to the nucleus. The presented results complement recent data that indicate that Kuz can perform the S2 proteolytic cleavage of the Notch receptor that is required for its activation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0949-944X
pubmed:author
pubmed:issnType
Print
pubmed:volume
212
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
251-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
kuzbanian is required cell autonomously during Notch signalling in the Drosophila wing.
pubmed:affiliation
Institute for Genetics, University of Cologne, Weyertal 121, 50931 Cologne. Germany. th.klein@uni-koeln.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't