rdf:type |
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lifeskim:mentions |
umls-concept:C0024977,
umls-concept:C0026336,
umls-concept:C0205314,
umls-concept:C0243077,
umls-concept:C0450363,
umls-concept:C0456387,
umls-concept:C0596902,
umls-concept:C0599682,
umls-concept:C0599740,
umls-concept:C0679622,
umls-concept:C1441547,
umls-concept:C1552603,
umls-concept:C1706202,
umls-concept:C1880355
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pubmed:issue |
13
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pubmed:dateCreated |
2002-6-17
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pubmed:abstractText |
Substituted 3,4-diphenyl-1,3-thiazols were identified as a class of novel and potent monoamine transporter inhibitors through a 3-D pharmacophore search using a new pharmacophore model derived from mazindol. The most potent compound (13) has K(i) values of 24 and 23 nM in binding to dopamine transporter and inhibition of dopamine reuptake, respectively.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/(1R-(exo,exo))-3-(4-fluorophenyl)-8-...,
http://linkedlifedata.com/resource/pubmed/chemical/Biphenyl Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Cocaine,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Plasma Membrane Transport...,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Uptake Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Mazindol,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazoles
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1775-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12067559-Binding Sites,
pubmed-meshheading:12067559-Biphenyl Compounds,
pubmed-meshheading:12067559-Cocaine,
pubmed-meshheading:12067559-Dopamine,
pubmed-meshheading:12067559-Dopamine Plasma Membrane Transport Proteins,
pubmed-meshheading:12067559-Dopamine Uptake Inhibitors,
pubmed-meshheading:12067559-Ligands,
pubmed-meshheading:12067559-Mazindol,
pubmed-meshheading:12067559-Membrane Glycoproteins,
pubmed-meshheading:12067559-Membrane Transport Proteins,
pubmed-meshheading:12067559-Models, Molecular,
pubmed-meshheading:12067559-Nerve Tissue Proteins,
pubmed-meshheading:12067559-Norepinephrine,
pubmed-meshheading:12067559-Serotonin,
pubmed-meshheading:12067559-Structure-Activity Relationship,
pubmed-meshheading:12067559-Thiazoles
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pubmed:year |
2002
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pubmed:articleTitle |
Discovery of substituted 3,4-diphenyl-thiazoles as a novel class of monoamine transporter inhibitors through 3-D pharmacophore search using a new pharmacophore model derived from mazindol.
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pubmed:affiliation |
Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109-0934, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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