Linked Life Data

12037726

Source:http://linkedlifedata.com/resource/pubmed/id/12037726

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2002-5-30
pubmed:abstractText
It is hypothesized that adhesion molecules could be an early predictor of coronary artery disease. Therefore we investigated the relationship between the concentrations of soluble forms of adhesion molecules and disturbances of glucose metabolism in 78 men referred for coronary angiography but with no previous history of diabetes. The group consisted of 78 men (mean age, 47.6 +/- 7.0 years; mean body mass index [BMI], 28.4 +/- 3.24 with the symptoms of angina pectoris and positive exercise test. All subjects were given a standard oral glucose tolerance test (OGTT) with glucose and insulin estimations. Fasting plasma concentrations of the soluble (s) forms of E-selectin, intercellular adhesion cell molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), and HbA(1c) were also measured. According to the OGTT, 10.2% of the patients (n = 8) fulfilled the criteria for type 2 diabetes mellitus and 44.9% (n = 35) for impaired glucose tolerance (IGT). The highest concentrations of sE-selectin were observed in patients with type 2 diabetes mellitus and were significantly higher in comparison to the group with normal glucose tolerance and IGT. The concentration of sVCAM-1 increased with the progression of disturbances of glucose metabolism and remained the highest in type 2 diabetic patients. sICAM-1 concentration was not significantly different. sE-selectin concentration correlated significantly with fasting glucose (r = 0.23, P =.041), postload glucose (r = 0.39, P =.001), and postload insulin (r = 0.28, P =.023). sVCAM-1 was significantly related to the postload glucose concentration (r = 0.30, P =.009). A significant correlation between sICAM-1 concentration and postload insulin was also observed (r = 0.27, P =.025). This would suggest that hyperglycemia increases sE-selectin and sVCAM-1 in plasma, which reflects excessive formation of atherosclerotic plaques in patients with disturbances of glucose metabolism.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0026-0495
pubmed:author
pubmed:copyrightInfo
Copyright 2002, Elsevier Science (USA). All rights reserved.
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
733-6
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:12037726-Biological Markers, pubmed-meshheading:12037726-Blood Glucose, pubmed-meshheading:12037726-Cholesterol, pubmed-meshheading:12037726-Cholesterol, HDL, pubmed-meshheading:12037726-Coronary Angiography, pubmed-meshheading:12037726-Coronary Artery Disease, pubmed-meshheading:12037726-Diabetes Mellitus, Type 2, pubmed-meshheading:12037726-Disease Progression, pubmed-meshheading:12037726-E-Selectin, pubmed-meshheading:12037726-Glucose, pubmed-meshheading:12037726-Glucose Intolerance, pubmed-meshheading:12037726-Glucose Tolerance Test, pubmed-meshheading:12037726-Hemoglobin A, Glycosylated, pubmed-meshheading:12037726-Humans, pubmed-meshheading:12037726-Hyperglycemia, pubmed-meshheading:12037726-Insulin, pubmed-meshheading:12037726-Intercellular Adhesion Molecule-1, pubmed-meshheading:12037726-Male, pubmed-meshheading:12037726-Middle Aged, pubmed-meshheading:12037726-Triglycerides, pubmed-meshheading:12037726-Vascular Cell Adhesion Molecule-1
pubmed:year
2002
pubmed:articleTitle
Circulating E-selectin, vascular cell adhesion molecule-1, and intercellular adhesion molecule-1 in men with coronary artery disease assessed by angiography and disturbances of carbohydrate metabolism.
pubmed:affiliation
Department of Endocrinology, Diabetology, and Internal Medicine, Medical Academy in Bia?ystok, Poland.
pubmed:publicationType
Journal Article, Clinical Trial