|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0021311,
umls-concept:C0029923,
umls-concept:C0035236,
umls-concept:C0205263,
umls-concept:C0301625,
umls-concept:C0389995,
umls-concept:C0458827,
umls-concept:C0667301,
umls-concept:C1171350,
umls-concept:C1325847,
umls-concept:C1335631
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2002-5-30
|
|
pubmed:abstractText |
Smooth muscle contraction is one of the hallmarks of asthma. A recently developed pyridine derivative, Y-27632, a selective Rho kinase inhibitor, has been reported to inhibit the smooth muscle contraction of human and animal trachea in ex vivo systems but its effect in animal models of airway hyperresponsiveness (AHR) has not been examined. The purpose of this study was to evaluate the effect of Y-27632 in a murine model of allergic and virally induced AHR.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12037228-10051251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12037228-10069508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12037228-10340938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12037228-10438814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12037228-10686302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12037228-10718987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12037228-10779382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12037228-10845430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12037228-1577714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12037228-1656467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12037228-2494163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12037228-2579657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12037228-2988424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12037228-3027524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12037228-3183639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12037228-6327916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12037228-7700748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12037228-7767192,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12037228-7969451,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12037228-8577766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12037228-8662509,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12037228-9139666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12037228-9353125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12037228-9860804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12037228-9862451,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12037228-9892406
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0040-6376
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
57
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
524-7
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:12037228-Airway Resistance,
pubmed-meshheading:12037228-Animals,
pubmed-meshheading:12037228-Antihypertensive Agents,
pubmed-meshheading:12037228-Asthma,
pubmed-meshheading:12037228-Benzopyrans,
pubmed-meshheading:12037228-Bronchial Hyperreactivity,
pubmed-meshheading:12037228-Dose-Response Relationship, Drug,
pubmed-meshheading:12037228-Female,
pubmed-meshheading:12037228-Lung,
pubmed-meshheading:12037228-Mice,
pubmed-meshheading:12037228-Mice, Inbred BALB C,
pubmed-meshheading:12037228-Ovalbumin,
pubmed-meshheading:12037228-Respiratory Syncytial Virus Infections
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
Suppression of airway hyperresponsiveness induced by ovalbumin sensitisation and RSV infection with Y-27632, a Rho kinase inhibitor.
|
|
pubmed:affiliation |
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-2582, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
