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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2002-5-28
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pubmed:abstractText |
In this experiment, we used direct electron paramagnetic resonance (EPR) spectra to measure lipid peroxidation by hydroxyl radical (.OH), nitric oxide (.NO) and lipid radical (.L). NMDA-receptor associated lipid peroxidation is thought to act through .OH in induction of neurotoxicity. The origin of .OH generation was found to arise mainly from peroxynitrite anion produced from O(2)(-) and .NO rather than from Fenton's reaction. This study verified that .OH generation from interactive reactions between .NO and O(2)(-) initiates NMDA-induced lipid peroxidation of PC12 cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0006-8993
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
941
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
107-12
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:12031552-Animals,
pubmed-meshheading:12031552-Blotting, Western,
pubmed-meshheading:12031552-Cell Line,
pubmed-meshheading:12031552-Electron Spin Resonance Spectroscopy,
pubmed-meshheading:12031552-Excitatory Amino Acid Agonists,
pubmed-meshheading:12031552-Hydroxyl Radical,
pubmed-meshheading:12031552-Lipid Peroxidation,
pubmed-meshheading:12031552-N-Methylaspartate,
pubmed-meshheading:12031552-Nitric Oxide,
pubmed-meshheading:12031552-PC12 Cells,
pubmed-meshheading:12031552-Rats,
pubmed-meshheading:12031552-Receptors, N-Methyl-D-Aspartate
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pubmed:year |
2002
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pubmed:articleTitle |
Nitric oxide and hydroxyl radicals initiate lipid peroxidation by NMDA receptor activation.
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pubmed:affiliation |
Department of Psychiatry, Miyazaki Medical College, 5200 Kihara, Kiyotake-cho, Miyazaki 889-1692, Japan.
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pubmed:publicationType |
Journal Article
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