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rdf:type |
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lifeskim:mentions |
umls-concept:C0086418,
umls-concept:C0109317,
umls-concept:C0127400,
umls-concept:C0162638,
umls-concept:C0205263,
umls-concept:C0291988,
umls-concept:C0334227,
umls-concept:C0346647,
umls-concept:C0532362,
umls-concept:C0752312,
umls-concept:C0950968,
umls-concept:C1150579,
umls-concept:C1333340,
umls-concept:C1366882,
umls-concept:C1370600,
umls-concept:C1705767,
umls-concept:C1705791
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pubmed:issue |
2A
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pubmed:dateCreated |
2002-5-16
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pubmed:abstractText |
Pancreatic carcinoma resists chemotherapeutic mediation of apoptosis. Irofulven (MGI 114, 6-hydroxymethylacylfulvene) is a novel illudin S analogue that we have shown to induce caspase-mediated apoptosis in pancreatic carcinoma cell lines.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4-(4-fluorophenyl)-2-(4-hydroxypheny...,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Alkylating,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Flavonoids,
http://linkedlifedata.com/resource/pubmed/chemical/Imidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 8,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/PD 98059,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/Sesquiterpenes,
http://linkedlifedata.com/resource/pubmed/chemical/irofulven,
http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...
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pubmed:status |
MEDLINE
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pubmed:issn |
0250-7005
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
559-64
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12014623-Antineoplastic Agents, Alkylating,
pubmed-meshheading:12014623-Apoptosis,
pubmed-meshheading:12014623-Caspases,
pubmed-meshheading:12014623-Enzyme Activation,
pubmed-meshheading:12014623-Enzyme Inhibitors,
pubmed-meshheading:12014623-Flavonoids,
pubmed-meshheading:12014623-Humans,
pubmed-meshheading:12014623-Imidazoles,
pubmed-meshheading:12014623-Isoenzymes,
pubmed-meshheading:12014623-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:12014623-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:12014623-Mitogen-Activated Protein Kinase 8,
pubmed-meshheading:12014623-Mitogen-Activated Protein Kinases,
pubmed-meshheading:12014623-Pancreatic Neoplasms,
pubmed-meshheading:12014623-Pyridines,
pubmed-meshheading:12014623-Sesquiterpenes,
pubmed-meshheading:12014623-Tumor Cells, Cultured,
pubmed-meshheading:12014623-p38 Mitogen-Activated Protein Kinases
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pubmed:articleTitle |
Irofulven (6-hydroxymethylacylfulvene, MGI 114)-induced apoptosis in human pancreatic cancer cells is mediated by ERK and JNK kinases.
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pubmed:affiliation |
Department of Surgery, University of Texas Health Science Center at San Antonio, 78229, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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