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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0017262,
umls-concept:C0020507,
umls-concept:C0020792,
umls-concept:C0033572,
umls-concept:C0040300,
umls-concept:C0079189,
umls-concept:C0162597,
umls-concept:C0185117,
umls-concept:C0205183,
umls-concept:C0205217,
umls-concept:C0449475,
umls-concept:C0596290,
umls-concept:C0682758,
umls-concept:C1171362,
umls-concept:C1280500,
umls-concept:C1515670,
umls-concept:C2911684
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pubmed:issue |
1
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pubmed:dateCreated |
2002-5-23
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pubmed:abstractText |
Benign prostatic hyperplasia (BPH) frequently exhibit infiltration of CD4 (+)/CD45RO (+) memory-T-lymphocytes. Expression and impact of lymphocyte-derived growth factors on prostatic stromal cell (PSC) growth were investigated. METHODS; Lymphokine synthesis in normal prostate tissues (n = 3), BPH-tissues (n = 13), BPH-derived T-cells (n = 6), BPH-derived epithelial cells (BPH-EC) (n = 5), normal prostate-derived (n = 3) and BPH-derived stromal cell lines (BPH-SC) (n = 6), and prostate cancer (CaP) lines (n = 3) was analyzed by RT-PCR and Southern-blotting. The effect of interleukin (IL)-2, -4, -7, and interferon-gamma (IFN-gamma) on normal and BPH-SC growth was investigated by (3)H-thymidine incorporation assays.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0270-4137
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2002 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
43-58
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11992619-Adolescent,
pubmed-meshheading:11992619-Adult,
pubmed-meshheading:11992619-Blotting, Southern,
pubmed-meshheading:11992619-Cell Division,
pubmed-meshheading:11992619-Clone Cells,
pubmed-meshheading:11992619-Cytokines,
pubmed-meshheading:11992619-Gene Expression,
pubmed-meshheading:11992619-Humans,
pubmed-meshheading:11992619-Interferon-gamma,
pubmed-meshheading:11992619-Interleukin-2,
pubmed-meshheading:11992619-Interleukin-4,
pubmed-meshheading:11992619-Interleukin-7,
pubmed-meshheading:11992619-Male,
pubmed-meshheading:11992619-Phenotype,
pubmed-meshheading:11992619-Prostatic Hyperplasia,
pubmed-meshheading:11992619-Prostatic Neoplasms,
pubmed-meshheading:11992619-RNA, Messenger,
pubmed-meshheading:11992619-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:11992619-Stromal Cells,
pubmed-meshheading:11992619-T-Lymphocytes,
pubmed-meshheading:11992619-Tumor Cells, Cultured
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pubmed:year |
2002
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pubmed:articleTitle |
Increased expression of lymphocyte-derived cytokines in benign hyperplastic prostate tissue, identification of the producing cell types, and effect of differentially expressed cytokines on stromal cell proliferation.
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pubmed:affiliation |
Department of Urology, University of Vienna, Vienna, Austria.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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