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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2002-4-30
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pubmed:abstractText |
T-cell costimulation has been shown to provide positive signals for T-cell activation and generation of effector activity. In this study, we analyzed the presence of antibodies (Abs) against the T-lymphocyte costimulatory molecules CD28, CTLA-4, CD80, and CD86 in anti-T-lymphocyte (ATG) and antithymocyte (TMG) globulin preparations to address their mechanism of action. We focused our attention on the role of CTLA-4-specific Abs in the immunosuppressive effect of ATG/TMG, because anti-CTLA-4 agonistic Abs may suppress T-cell proliferation and nonagonistic Abs may lead to T-cell depletion through an Ab-dependent cell cytotoxicity mechanism.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD28,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD86,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Antilymphocyte Serum,
http://linkedlifedata.com/resource/pubmed/chemical/CD86 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cd86 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Ctla4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoconjugates,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin Fc Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/abatacept
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0041-1337
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
73
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1295-302
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:11981425-Animals,
pubmed-meshheading:11981425-Antibody Specificity,
pubmed-meshheading:11981425-Antigens, CD,
pubmed-meshheading:11981425-Antigens, CD28,
pubmed-meshheading:11981425-Antigens, CD80,
pubmed-meshheading:11981425-Antigens, CD86,
pubmed-meshheading:11981425-Antigens, Differentiation,
pubmed-meshheading:11981425-Antilymphocyte Serum,
pubmed-meshheading:11981425-CTLA-4 Antigen,
pubmed-meshheading:11981425-Hematologic Neoplasms,
pubmed-meshheading:11981425-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:11981425-Humans,
pubmed-meshheading:11981425-Immunoconjugates,
pubmed-meshheading:11981425-Immunoglobulin Fc Fragments,
pubmed-meshheading:11981425-Immunosuppressive Agents,
pubmed-meshheading:11981425-Membrane Glycoproteins,
pubmed-meshheading:11981425-Mice,
pubmed-meshheading:11981425-Multiple Myeloma,
pubmed-meshheading:11981425-Recombinant Fusion Proteins,
pubmed-meshheading:11981425-Recombinant Proteins,
pubmed-meshheading:11981425-T-Lymphocytes,
pubmed-meshheading:11981425-Thymus Gland,
pubmed-meshheading:11981425-Tumor Cells, Cultured
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pubmed:year |
2002
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pubmed:articleTitle |
Detection of a novel specificity (CTLA-4) in ATG/TMG globulins and sera from ATG-treated leukemic patients.
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pubmed:affiliation |
Immunogenetics Laboratory, National Cancer Research Institute, Advanced Biotechnology Center, Genova, Italy. pistillo@vega.cba.unige.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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