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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2002-4-30
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pubmed:abstractText |
We conducted an expression analysis of prostate stem cell antigen (PSCA)in normal urogenital tissues, benign prostatic hyperplasia (n = 21), prostatic intraepithelial neoplasia (n = 33), and primary (n = 137) and metastatic (n = 42) prostate adenocarcinoma, using isotopic in situ hybridization on tissue microarrays. In normal prostate, we observe PSCA expression in the terminally differentiated, secretory epithelium; strong expression was also seen in normal urothelium. Forty-eight percent of primary and 64% of metastatic prostatic adenocarcinomas expressed PSCA RNA. Our studies did not confirm a positive correlation between level of PSCA RNA expression and high Gleason grade. We characterized monoclonal anti-PSCA antibodies that recognize PSCA expressed on the surface of live cells, are efficiently internalized after antigen recognition, and kill tumor cells in vitro in an antigen-specific fashion upon conjugation with maytansinoid. Unconjugated anti-PSCA antibodies demonstrated efficacy against PSCA-positive tumors by delaying progressive tumor growth in vivo. Maytansinoid-conjugated antibodies caused complete regression of established tumors in a large proportion of animals. Our results strongly suggest that maytansinoid-conjugated anti-PSCA monoclonal antibodies should be evaluated as a therapeutic modality for patients with advanced prostate cancer.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/GPI-Linked Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Immunotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Maytansine,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PSCA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Psca protein, mouse
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0008-5472
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pubmed:author |
pubmed-author:DevauxBrigitteB,
pubmed-author:EberhardDavidD,
pubmed-author:FrantzGretchenG,
pubmed-author:HillanKennethK,
pubmed-author:HolcombIlonaI,
pubmed-author:HongoJoAnneJ,
pubmed-author:KellerGilbert AGA,
pubmed-author:KoeppenHartmutH,
pubmed-author:LaskyLaurence ALA,
pubmed-author:LutzRobert JRJ,
pubmed-author:PealeFranklinF,
pubmed-author:RangellLindaL,
pubmed-author:RossSarajaneS,
pubmed-author:RubinMark AMA,
pubmed-author:SchowPeterP,
pubmed-author:SpencerSusan DSD,
pubmed-author:SteevesRita MRM,
pubmed-author:TanChristineC,
pubmed-author:TobinPattiP
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2546-53
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:11980648-Adenocarcinoma,
pubmed-meshheading:11980648-Adult,
pubmed-meshheading:11980648-Aged,
pubmed-meshheading:11980648-Aged, 80 and over,
pubmed-meshheading:11980648-Animals,
pubmed-meshheading:11980648-Antibodies, Monoclonal,
pubmed-meshheading:11980648-Antigens, Neoplasm,
pubmed-meshheading:11980648-Female,
pubmed-meshheading:11980648-GPI-Linked Proteins,
pubmed-meshheading:11980648-Humans,
pubmed-meshheading:11980648-Immunization, Passive,
pubmed-meshheading:11980648-Immunotoxins,
pubmed-meshheading:11980648-In Situ Hybridization,
pubmed-meshheading:11980648-Male,
pubmed-meshheading:11980648-Maytansine,
pubmed-meshheading:11980648-Membrane Glycoproteins,
pubmed-meshheading:11980648-Mice,
pubmed-meshheading:11980648-Mice, Inbred BALB C,
pubmed-meshheading:11980648-Mice, Nude,
pubmed-meshheading:11980648-Middle Aged,
pubmed-meshheading:11980648-Neoplasm Proteins,
pubmed-meshheading:11980648-Prostatic Neoplasms
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pubmed:year |
2002
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pubmed:articleTitle |
Prostate stem cell antigen as therapy target: tissue expression and in vivo efficacy of an immunoconjugate.
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pubmed:affiliation |
Department of Pathology, Genentech, Inc., South San Francisco, California 94080, USA.
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pubmed:publicationType |
Journal Article
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