| pubmed-article:11973310 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11973310 | lifeskim:mentions | umls-concept:C1257890 | lld:lifeskim |
| pubmed-article:11973310 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:11973310 | lifeskim:mentions | umls-concept:C0012940 | lld:lifeskim |
| pubmed-article:11973310 | lifeskim:mentions | umls-concept:C0013138 | lld:lifeskim |
| pubmed-article:11973310 | lifeskim:mentions | umls-concept:C0600508 | lld:lifeskim |
| pubmed-article:11973310 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:11973310 | lifeskim:mentions | umls-concept:C0083956 | lld:lifeskim |
| pubmed-article:11973310 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:11973310 | lifeskim:mentions | umls-concept:C1510941 | lld:lifeskim |
| pubmed-article:11973310 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:11973310 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:11973310 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:11973310 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:11973310 | pubmed:dateCreated | 2002-4-25 | lld:pubmed |
| pubmed-article:11973310 | pubmed:abstractText | Regulatory DNA from the Drosophila gene engrailed causes silencing of a linked reporter gene (mini-white) in transgenic Drosophila. This silencing is strengthened in flies homozygous for the transgene and has been called "pairing-sensitive silencing." The pairing-sensitive silencing activities of a large fragment (2.6 kb) and a small subfragment (181 bp) were explored. Since pairing-sensitive silencing is often associated with Polycomb group response elements (PREs), we tested the activities of each of these engrailed fragments in a construct designed to detect PRE activity in embryos. Both fragments were found to behave as PREs in a bxd-Ubx-lacZ reporter construct, while the larger fragment showed additional silencing capabilities. Using the mini-white reporter gene, a 139-bp minimal pairing-sensitive element (PSE) was defined. DNA mobility-shift assays using Drosophila nuclear extracts suggested that there are eight protein-binding sites within this 139-bp element. Mutational analysis showed that at least five of these sites are important for pairing-sensitive silencing. One of the required sites is for the Polycomb group protein Pleiohomeotic and another is GAGAG, a sequence bound by the proteins GAGA factor and Pipsqueak. The identity of the other proteins is unknown. These data suggest a surprising degree of complexity in the DNA-binding proteins required for PSE function. | lld:pubmed |
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| pubmed-article:11973310 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11973310 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11973310 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11973310 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11973310 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11973310 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:11973310 | pubmed:issn | 0016-6731 | lld:pubmed |
| pubmed-article:11973310 | pubmed:author | pubmed-author:FujiokaMikiM | lld:pubmed |
| pubmed-article:11973310 | pubmed:author | pubmed-author:JaynesJames... | lld:pubmed |
| pubmed-article:11973310 | pubmed:author | pubmed-author:KassisJudith... | lld:pubmed |
| pubmed-article:11973310 | pubmed:author | pubmed-author:AmericoJeffre... | lld:pubmed |
| pubmed-article:11973310 | pubmed:author | pubmed-author:WhiteleyMaryM | lld:pubmed |
| pubmed-article:11973310 | pubmed:author | pubmed-author:BrownJ... | lld:pubmed |
| pubmed-article:11973310 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11973310 | pubmed:volume | 160 | lld:pubmed |
| pubmed-article:11973310 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11973310 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11973310 | pubmed:pagination | 1561-71 | lld:pubmed |
| pubmed-article:11973310 | pubmed:dateRevised | 2011-5-4 | lld:pubmed |
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| pubmed-article:11973310 | pubmed:meshHeading | pubmed-meshheading:11973310... | lld:pubmed |
| pubmed-article:11973310 | pubmed:meshHeading | pubmed-meshheading:11973310... | lld:pubmed |
| pubmed-article:11973310 | pubmed:meshHeading | pubmed-meshheading:11973310... | lld:pubmed |
| pubmed-article:11973310 | pubmed:meshHeading | pubmed-meshheading:11973310... | lld:pubmed |
| pubmed-article:11973310 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11973310 | pubmed:articleTitle | A complex array of DNA-binding proteins required for pairing-sensitive silencing by a polycomb group response element from the Drosophila engrailed gene. | lld:pubmed |
| pubmed-article:11973310 | pubmed:affiliation | Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA. | lld:pubmed |
| pubmed-article:11973310 | pubmed:publicationType | Journal Article | lld:pubmed |
