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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6882
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pubmed:dateCreated |
2002-4-18
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pubmed:abstractText |
During the growth of Drosophila imaginal discs a process called 'cell competition' eliminates slow-proliferating but otherwise viable cells. We report here that cell competition requires the function of the brinker (brk) gene, whose expression is normally repressed by Decapentaplegic (Dpp) signalling but is upregulated in slow-growing Minute/+ cells. Excess brk expression activates the c-Jun amino-terminal kinase pathway, which in turn triggers apoptosis in these cells. We propose that slow-proliferating cells upregulate Brk levels owing to a disadvantage in competing for, or in transducing, the Dpp survival signal. This sequence of events might represent a general mechanism by which weaker cells are eliminated from a growing population, and might serve as a method of controlling cell number and optimizing tissue fitness and hence organ function.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
416
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
755-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11961558-Animals,
pubmed-meshheading:11961558-Apoptosis,
pubmed-meshheading:11961558-Clone Cells,
pubmed-meshheading:11961558-Drosophila Proteins,
pubmed-meshheading:11961558-Drosophila melanogaster,
pubmed-meshheading:11961558-Endocytosis,
pubmed-meshheading:11961558-Female,
pubmed-meshheading:11961558-Gene Expression Regulation, Developmental,
pubmed-meshheading:11961558-Genes, Reporter,
pubmed-meshheading:11961558-Insect Proteins,
pubmed-meshheading:11961558-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:11961558-Mitogen-Activated Protein Kinases,
pubmed-meshheading:11961558-Mitosis,
pubmed-meshheading:11961558-Recombination, Genetic,
pubmed-meshheading:11961558-Repressor Proteins,
pubmed-meshheading:11961558-Signal Transduction,
pubmed-meshheading:11961558-Transcription Factors,
pubmed-meshheading:11961558-Up-Regulation,
pubmed-meshheading:11961558-Wing
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pubmed:year |
2002
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pubmed:articleTitle |
Cells compete for decapentaplegic survival factor to prevent apoptosis in Drosophila wing development.
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pubmed:affiliation |
Institut für Molekularbiologie, Universität Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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