Source:http://linkedlifedata.com/resource/pubmed/id/11960307
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2002-4-17
|
| pubmed:abstractText |
CD30-CD30 ligand (CD30L) signal transduction appears to protect against autoimmune diabetes by preventing expansion of autoreactive T cells and suppressing Th1-cytokine response. The purpose of this study was to determine whether CD30 or CD30L genes serve as a novel susceptibility gene for type 1 diabetes in humans. We screened CD30 and CD30L genes for polymorphisms in Japanese patients with type 1 diabetes and control subjects. Then, association studies were performed between each of the identified polymorphisms and type 1 diabetes. Direct-sequencing analysis of the CD30 and CD30L genes revealed four polymorphisms: one in the CD30 gene (-201G/A from the transcription start site), and three in the CD30L gene [CA repeat in the promoter, 276G/A in the exon 3, -73T/C in the intron 3 (IVS3 -73T/C)]. Association studies revealed no association between the CD30 and CD30L genes and type 1 diabetes in the whole population. In the female and male subpopulations, however, the frequency of (CA)(9) allele of the CD30L gene promoter or T allele of IVS3 -73T/C polymorphism in the CD30L gene was slightly higher in female patients with type 1 diabetes than that in control females. In conclusion, we could not find significant association between CD30 or CD30L genes and type 1 diabetes, but (CA)(9) allele in the promotor or T allele of -73T/C in intron 3 in CD30L gene might play a minor role in the pathogenesis of type 1 diabetes, only in the Japanese female population.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
|
| pubmed:issn |
1466-4879
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
3
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
96-101
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:11960307-Adolescent,
pubmed-meshheading:11960307-Antigens, CD30,
pubmed-meshheading:11960307-CD30 Ligand,
pubmed-meshheading:11960307-Child,
pubmed-meshheading:11960307-Child, Preschool,
pubmed-meshheading:11960307-Diabetes Mellitus, Type 1,
pubmed-meshheading:11960307-Female,
pubmed-meshheading:11960307-Gene Frequency,
pubmed-meshheading:11960307-Genetic Predisposition to Disease,
pubmed-meshheading:11960307-Genotype,
pubmed-meshheading:11960307-Humans,
pubmed-meshheading:11960307-Infant,
pubmed-meshheading:11960307-Infant, Newborn,
pubmed-meshheading:11960307-Japan,
pubmed-meshheading:11960307-Linkage Disequilibrium,
pubmed-meshheading:11960307-Male,
pubmed-meshheading:11960307-Membrane Glycoproteins,
pubmed-meshheading:11960307-Polymorphism, Genetic,
pubmed-meshheading:11960307-Promoter Regions, Genetic
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Association study between CD30 and CD30 ligand genes and type 1 diabetes in the Japanese population.
|
| pubmed:affiliation |
Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|