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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-4-17
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pubmed:abstractText |
Chronic heart failure (CHF) has emerged as an insulin-resistant state, independently of ischaemic aetiology. The underlying mechanisms of this finding are not known. Catecholamines, tumor necrosis factor alpha (TNFalpha) and leptin, the adipocyte specific hormone, have all been implicated as mediators of impaired insulin sensitivity. The purpose of this study was to examine in patients with CHF and in comparison to healthy controls subjects whether norepinephrine, TNFalpha or leptin relate to insulin sensitivity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0167-5273
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
73-81
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:11959387-Adipose Tissue,
pubmed-meshheading:11959387-Blood Glucose,
pubmed-meshheading:11959387-Blood Pressure,
pubmed-meshheading:11959387-Chronic Disease,
pubmed-meshheading:11959387-Creatinine,
pubmed-meshheading:11959387-Cross-Sectional Studies,
pubmed-meshheading:11959387-Heart Failure,
pubmed-meshheading:11959387-Humans,
pubmed-meshheading:11959387-Insulin,
pubmed-meshheading:11959387-Insulin Resistance,
pubmed-meshheading:11959387-Leptin,
pubmed-meshheading:11959387-Male,
pubmed-meshheading:11959387-Middle Aged,
pubmed-meshheading:11959387-Multivariate Analysis,
pubmed-meshheading:11959387-Norepinephrine,
pubmed-meshheading:11959387-Oxygen Consumption,
pubmed-meshheading:11959387-Predictive Value of Tests,
pubmed-meshheading:11959387-Sensitivity and Specificity,
pubmed-meshheading:11959387-Sodium,
pubmed-meshheading:11959387-Tumor Necrosis Factor-alpha
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pubmed:year |
2002
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pubmed:articleTitle |
Insulin resistance in moderate chronic heart failure is related to hyperleptinaemia, but not to norepinephrine or TNF-alpha.
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pubmed:affiliation |
Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse St., London SW3 6LY, UK. w.doehner@ic.ac.uk
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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