Source:http://linkedlifedata.com/resource/pubmed/id/11914659
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2002-3-26
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| pubmed:abstractText |
Abnormal levels of soluble intercellular adhesion molecule-1 (sICAM-1), C-reactive protein (CRP) and von Willebrand factor (vWf) are commonly found in breast and other cancers. However, the relationship between these molecules is unclear as raised sICAM-1 and vWf may simply reflect an acute phase response. We tested the hypothesis that raised sICAM-1 and vWf are related to the acute phase response by measuring both markers by enzyme-linked immunosorbent assay, and CRP by dry chemistry, in 40 women with breast cancer (cases) and 40 age-matched controls. All three markers were raised in the cases compared with the controls [sICAM-1 (mean +/- SD), 281 +/- 70 versus 230 +/- 40 ng/ml; vWf (mean +/- SD), 139 +/- 33 versus 106 +/- 16 IU/dl; CRP (median), 7 (interquartile range, 5-11) versus 5 (4-6) mg/dl; all P < 0.01]. However, sICAM-1 correlated strongly with CRP (r = 0.67, P < 0.001) in the cases but there was no significant relationship between vWf and CRP (r = -0.15, P = 0.351). There were no significant correlations in the controls. We conclude that raised sICAM-1 in breast cancer, like the acute phase response, reflects inflammation, and that raised vWf seems likely to be independent of the acute phase response.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/C-Reactive Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Adhesion Molecule-1,
http://linkedlifedata.com/resource/pubmed/chemical/von Willebrand Factor
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| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
0957-5235
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
13
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
165-8
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:11914659-Acute-Phase Reaction,
pubmed-meshheading:11914659-Biological Markers,
pubmed-meshheading:11914659-Breast Neoplasms,
pubmed-meshheading:11914659-C-Reactive Protein,
pubmed-meshheading:11914659-Case-Control Studies,
pubmed-meshheading:11914659-Female,
pubmed-meshheading:11914659-Humans,
pubmed-meshheading:11914659-Inflammation,
pubmed-meshheading:11914659-Intercellular Adhesion Molecule-1,
pubmed-meshheading:11914659-Solubility,
pubmed-meshheading:11914659-Statistics, Nonparametric,
pubmed-meshheading:11914659-von Willebrand Factor
|
| pubmed:year |
2002
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| pubmed:articleTitle |
Increased soluble intercellular adhesion molecule-1, breast cancer and the acute phase response.
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| pubmed:affiliation |
University Department of Surgery, University Hospital of South Manchester, Manchester, UK. a.blann@bham.ac.uk
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| pubmed:publicationType |
Journal Article
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